+ Site Statistics
+ Search Articles
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ PDF Full Text
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Translate
+ Recently Requested

Oxidative Status in Epileptic Children Using Carbamazepine

Oxidative Status in Epileptic Children Using Carbamazepine

Iranian Journal of Pediatrics 25(6): E3885

There is an increasing attention towards the relationship between oxidative stress and epilepsy. The effect of antiepileptic drugs on oxidant status is of major interest. Antiepileptic drugs can increase levels of free radicals, which consequently might lead to seizures. Carbamazepine (CBZ) is an antiepileptic drug commonly used in childhood and adolescence. Therefore we aimed to investigate the effects of CBZ on total antioxidant status, total oxidant stress, and oxidative stress index. The study included 40 epileptic patients and 31 healthy children between 4 and 12 years of age. Serum CBZ level, total antioxidant capacity and total oxidant status were measured. Oxidative stress index was also calculated both in controls and patients. In the epileptic group, decreased levels of total antioxidant capacity, increased total oxidative stress and oxidative stress index levels were found. Positive correlation between plasma CBZ levels and total oxidant status was observed. Antioxidant action could not be playing any role in antiepileptic effect of CBZ. Furthermore, increased oxidative stress induced by CBZ could be the cause of CBZ-induced seizures. Therefore combining CBZ with antioxidants could be beneficial.

(PDF emailed within 1 workday: $29.90)

Accession: 058488475

Download citation: RISBibTeXText

PMID: 26635944

Related references

The effects of carbamazepine, valproic acid and phenobarbital on the oxidative and antioxidative balance in epileptic children. European Neurology 57(2): 65-69, 2006

Carbamazepine, carbamazepine-10,11-epoxide and phenytoin concentrations in brain tissue of epileptic children. Acta Neurologica Scandinavica 58(2): 104-108, 1978

Carbamazepine--erythromycin interaction leading to carbamazepine toxicity in four epileptic children. Therapeutic Drug Monitoring 5(4): 405-407, 1983

Fluctuations in salivary carbamazepine and carbamazepine-10,11-epoxide concentrations during the day in epileptic children. Epilepsia 24(6): 716-724, 1983

Factors influencing plasma concentrations of carbamazepine and carbamazepine-10,11-epoxide in epileptic children and adults. Therapeutic Drug Monitoring 17(1): 47-52, 1995

Relationships between carbamazepine-diol, carbamazepine-epoxide, and carbamazepine total and free steady-state concentrations in epileptic patients: the influence of age, sex, and comedication. Therapeutic Drug Monitoring 18(6): 660-665, 1996

Use of saliva in monitoring carbamazepine medication in epileptic children. European Journal of Pediatrics 126(1-2): 37-44, 1977

Erythromycin-induced carbamazepine intoxication in two epileptic children. Japanese Journal of Psychiatry and Neurology 43(3): 513-514, 1989

Carbamazepine as first line treatment in epileptic children and adolescents. Epilepsia 32(SUPPL 1): 23, 1991

Carbamazepine treatment of epileptic and psychic symptoms in children and adolescents. Annales Paediatriae Fenniae 11(2): 91-97, 1965

The treatment of epileptic children with carbamazepine. Follow-up studies of clinical course and EEG. Epilepsia 13(6): 819-828, 1972

Serum lipids in epileptic children treated with carbamazepine and valproate. European Journal of Pediatrics 156(7): 565-567, 1997

Effect of carbamazepine therapy on vitamin D and parathormone in epileptic children. Pediatric Neurology 43(5): 320-324, 2011

Carbamazepine and carbamazepine-10,11-epoxide serum concentrations in epileptic children. Journal of Pediatrics 106(3): 491-495, 1985