+ Site Statistics
References:
54,258,434
Abstracts:
29,560,870
PMIDs:
28,072,757
+ Search Articles
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ PDF Full Text
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Translate
+ Recently Requested

Oxidative Stress and Antioxidant Defense in Endometriosis and Its Malignant Transformation



Oxidative Stress and Antioxidant Defense in Endometriosis and Its Malignant Transformation



Oxidative Medicine and Cellular Longevity 2015: 848595



The aim of this study was to investigate the role of redox status in endometriosis and its malignant transformation. A search was conducted between 1990 and 2014 through the English language literature (online MEDLINE PubMed database) using the keywords endometriosis combined with malignant transformation, oxidative stress, and antioxidant defense. In benign endometriosis, autoxidation and Fenton reaction of hemoglobin from the ferrous Fe(2+) (oxyhemoglobin) state to the ferric Fe(3+) (methemoglobin) state lead to production of excess reactive oxygen species (ROS) such as O2(-) and (∙)OH. Hemoglobin, heme, and iron derivatives in endometriotic cysts cause distortion in the homeostatic redox balance. Excess oxidative stress could trigger DNA damage and cell death. In contrast, endometriosis-associated ovarian cancer (EAOC) might be associated with an effective antioxidant defense, including heme oxygenases, cytochrome P450 family, and glutathione transferase family. The pattern of redox balance supports that enhanced antioxidants may be involved in the pathogenesis of malignant transformation. In conclusion, oxidant/antioxidant balance function is a double-edged sword, promoting cell death or carcinogenesis. Upregulation of antioxidant functions in endometriotic cyst may result in restoration of cell survival and subsequent malignant transformation.

(PDF emailed within 0-6 h: $19.90)

Accession: 058488539

Download citation: RISBibTeXText

PMID: 26185594

DOI: 10.1155/2015/848595


Related references

Investigation of oxidative stress and antioxidant defense in patients with hepatitis B virus infection and the effect of interferon-alpha plus lamivudine combination therapy on oxidative stress. Mikrobiyoloji Bulteni 43(3): 411-423, 2010

Involvement of reactive oxygen species in emotional stress: A hypothesis based on the immobilization stress-induced oxidative damage and antioxidant defense changes in rat brain, and the effect of antioxidant treatment with reduced glutathione. International Journal of Stress Management 1(3): 249-263, 1994

Oxidative stress and antioxidant defense. World Allergy Organization Journal 5(1): 9-19, 2012

Drought stress induces oxidative stress and the antioxidant defense system in ascorbate-deficientvtc1mutants ofArabidopsis thaliana. Acta Physiologiae Plantarum 35(4): 1189-1200, 2013

Antioxidant defense systems and oxidative stress. Vigo-Pelfrey, C (Ed ) Membrane Lipid Oxidation, Vol Ii Viii+209p Crc Press, Inc : Boca Raton, Florida, Usa Illus 151-170, 1991

Free radicals, oxidative stress and antioxidant defense. Phytomedica 21(1/2): 1-8, 2000

Oxidative stress and antioxidant defense in malarial parasites. Molecular approaches to malaria: 365-383, 2005

Oxidative stress, antioxidant defense, and liver injury. Kaplowitz, Neil , Reprint Author, DeLeve, Laurie D , Reprint Author Drug-induced liver disease: 35-53, 2003

Transport stress-induced cerebrum oxidative stress is not mitigated by activating the Nrf2 antioxidant defense response in newly hatched chicks. Journal of Animal Science 95(7): 2871-2878, 2017

Effect of microgravity on antioxidant defense and oxidative stress in rat liver. FASEB Journal 10(3): A740, 1996

Oxidative stress and antioxidant defense in patients with chronic hepatitis B. Clinical Laboratory 58(3-4): 273-280, 2012

Concepts of oxidative stress and antioxidant defense in Crohn's disease. World Journal of Gastroenterology 19(39): 6540-6547, 2014

Oxidative stress and antioxidant defense in Egyptian favism patients. European Review for Medical and Pharmacological Sciences 17(9): 1211-1217, 2013

Active defense under oxidative stress. The antioxidant responsive element. Biochemistry. Biokhimiia 71(9): 962-974, 2006

Antioxidant defense and oxidative stress in children with acute hepatitis A. Annals of Saudi Medicine 31(3): 258-262, 2011