+ Site Statistics
+ Search Articles
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ PDF Full Text
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Translate
+ Recently Requested

Oxidative and nitrosative stress in serum of patients with Parkinson's disease

Oxidative and nitrosative stress in serum of patients with Parkinson's disease

Neurological Sciences 37(11): 1793-1798

Parkinson's disease (PD) is one of the common neurodegenerative disorders. Oxidative stress is considered as a contributing factor to the development of PD. The present study aims to investigate serum oxidative stress status in patients with PD. Oxidative stress was assessed by measuring serum nitric oxide levels, lipid hydroperoxide concentrations, and nitric oxide synthase activity. In addition, total serum antioxidant capacity (TAC) was evaluated using the serum 2,2-Diphenyl-1-picryl-hydrazyl (DPPH) free-radical scavenging method in 32 patient with Parkinson's disease and 32 control subjects. Our results indicated that serum nitric oxide and lipid hydroperoxide levels were significantly lower in patients with PD than controls. Moreover, nitric oxide levels were found to be negatively correlated with Unified Parkinson's Disease Rating Scale (UPDRS). However, no statistical difference was observed in total serum antioxidant capacities and nitric oxide synthase activities between patients and controls. The present study indicates that although antioxidant capacity was not changed, lipid hydroperoxide (LPO) level was found decreased. This might show pre-oxidative process in these patients. In addition, decreased nitric oxide (NO) level and negative correlation observed between NO level and disease rating scale implicated a role for NO in the disease process.

(PDF emailed within 0-6 h: $19.90)

Accession: 058488680

Download citation: RISBibTeXText

PMID: 27423450

DOI: 10.1007/s10072-016-2663-1

Related references

Oxidative and nitrosative stress in Parkinson's disease. Biochimica et Biophysica Acta 1792(7): 643-650, 2009

Gut Permeability and Microbiota in Parkinson's Disease: Role of Depression, Tryptophan Catabolites, Oxidative and Nitrosative Stress and Melatonergic Pathways. Current Pharmaceutical Design 22(40): 6142-6151, 2016

Involvement of oxidative and nitrosative stress in promoting retinal vasculitis in patients with Eales' disease. Clinical Biochemistry 36(5): 377-385, July, 2003

May the evaluation of nitrosative stress through selective increase of 3-nitrotyrosine proteins other than nitroalbumin and dominant tyrosine-125/136 nitrosylation of serum α-synuclein serve for diagnosis of sporadic Parkinson's disease?. Antioxidants and Redox Signaling 19(9): 912-918, 2014

Studying nitrosative stress in Parkinson's disease. Methods in Molecular Biology 1292: 195-201, 2015

Parkinson's disease is associated with oxidative stress: Comparison of peripheral antioxidant profiles in living Parkinson's, Alzheimer's and vascular dementia patients. Journal of Neural Transmission 108(10): 1135-1148, October, 2001

Nitric oxide and peroxynitrite serum levels in Parkinson's disease: correlation of oxidative stress and the severity of the disease. European Review for Medical and Pharmacological Sciences 17(7): 964-970, 2013

Effect of metformin on oxidative stress, nitrosative stress and inflammatory biomarkers in type 2 diabetes patients. Diabetes Research and Clinical Practice 93(1): 56-62, 2012

Evaluation of nitrosative and oxidative stress in Behçet disease. Journal of the European Academy of Dermatology and Venereology 19(2): 167-171, 2005

Oxidative and nitrosative stress in kidney disease: a case for cyclosporine A. Journal of Nephrology 18(4): 453-457, 2005

Biomarkers of oxidative/nitrosative stress: an approach to disease prevention. Acta Medica Okayama 61(4): 181-189, 2007

Neutrophils: The Role of Oxidative and Nitrosative Stress in Health and Disease. Advances in Experimental Medicine and Biology 857: 51-60, 2015

Evaluation of oxidative and nitrosative stress in hemodialysis patients. Minerva Medica 101(5): 305-310, 2011