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Oxidative inter-/intermolecular alkene diamination of hydroxy styrenes with electron-rich amines

Oxidative inter-/intermolecular alkene diamination of hydroxy styrenes with electron-rich amines

Organic Letters 17(10): 2558-2561

Doubly intermolecular alkene diamination is achieved with electron-rich, terminal alkenes through the use of a hypervalent iodine (PhI(OAc)2) reagent, iodide, and electron-rich amines. Mono- and disubstituted amines combine with electron-rich alkenes, particularly o-hydroxystyrenes, to achieve the greatest level of generality. This operationally straightforward protocol, unreliant on conventional metal-based activation, is compatible with a broad range of functional groups.

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Accession: 058488773

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PMID: 25942322

DOI: 10.1021/acs.orglett.5b01177

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