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Oxidative rearrangement of cyclobutanone derived N,O-ketals leading to pyrrolidone derivatives

Oxidative rearrangement of cyclobutanone derived N,O-ketals leading to pyrrolidone derivatives

Chemical and Pharmaceutical Bulletin 63(4): 245-247

A halogen-induced oxidative rearrangement of N,O-ketals prepared from cyclobutanones, leading to pyrrolidone derivatives, is developed. The reaction proceeds via an iminium ether intermediate and, depending on the reaction medium, two types of pyrrolidone derivative, containing a halogen atom or hydroxyl group, can be obtained.

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Accession: 058488824

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PMID: 25832019

DOI: 10.1248/cpb.c14-00856

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