+ Site Statistics
+ Search Articles
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ PDF Full Text
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Translate
+ Recently Requested

Oxidative stress and renal toxicity after subacute exposure to decabrominated diphenyl ether in Wistar rats

Oxidative stress and renal toxicity after subacute exposure to decabrominated diphenyl ether in Wistar rats

Environmental Science and Pollution Research International 25(8): 7223-7230

Fully brominated diphenyl ether (BDE-209) is a flame retardant widely used in plastics and textiles. Because of its high persistence, humans are exposed to it continuously, mainly via dust ingestion. We investigated effects of BDE-209 on renal function and oxidative stress development in the kidney after subacute exposure in rats. Five groups of animals were given by oral gavage 31.25-500 mg BDE-209/kg b.w./day for 28 days, and relative kidney weight, serum urea and creatinine, and oxidative stress parameters in the kidney were determined. Benchmark-dose approach was used for dose response modeling. Serum creatinine was increased, while results obtained for serum urea were inconclusive. Relative kidney weight was not affected by BDE-209. Kidney reduced glutathione was elevated, while superoxide dismutase activity was not changed after BDE-209 treatment. Also, levels of thiobarbituric acid reactive substances (TBARS) were increased and total -SH groups were decreased, which indicated oxidative imbalance. The critical effect dose (CED)/CEDL ratios for the effects on TBARS and total -SH groups indicated estimated CEDs for these markers can be used in risk assessment of BDE-209. Our study results have shown that a relatively low dose of BDE-209 affects kidney function and that oxidative stress is one of the mechanisms of its nephrotoxicity.

(PDF emailed within 0-6 h: $19.90)

Accession: 058488982

Download citation: RISBibTeXText

PMID: 26676538

DOI: 10.1007/s11356-015-5921-5

Related references

Developmental exposure to decabrominated diphenyl ether (BDE-209): effects on sperm oxidative stress and chromatin DNA damage in mouse offspring. Environmental Toxicology 28(7): 380-389, 2013

Relationship of hepatotoxicity and the target tissue dose of decabrominated diphenyl ether in subacutely exposed Wistar rats. Vojnosanitetski Pregled 72(5): 405-413, 2015

Absorption, tissue distribution, metabolism, and elimination of decabrominated diphenyl ether (BDE-209) in rats after multi-dose oral exposure. Chemosphere 186: 749-756, 2017

Effects of decabrominated diphenyl ether (PBDE 209) exposure at different developmental periods on synaptic plasticity in the dentate gyrus of adult rats In vivo. Toxicological Sciences 110(2): 401-410, 2009

Assessment of the neurotoxic mechanisms of decabrominated diphenyl ether (PBDE-209) in primary cultured neonatal rat hippocampal neurons includes alterations in second messenger signaling and oxidative stress. Toxicology Letters 192(3): 431-439, 2010

Oxidative stress responses in Wistar rats on subacute exposure to pharmaceutical wastewater. Environmental Science and Pollution Research International 23(23): 24158-24165, 2016

Comparative tissue distribution, biotransformation and associated biological effects by decabromodiphenyl ethane and decabrominated diphenyl ether in male rats after a 90-day oral exposure study. Environmental Science and Technology 44(14): 5655-5660, 2010

Effect of decabrominated diphenyl ether exposure on spatial learning and memory, the expression and phosphorylation of hippocampal glutamate receptor subunits in adult Sprague-Dawley rats. Journal of Toxicological Sciences 43(11): 645-657, 2018

Effects of repeated exposure to decabrominated diphenyl ether (BDE-209) on mice nervous system and its self repair. Environmental Toxicology and Pharmacology 29(3): 297-301, 2010

Tissue distribution of decabrominated diphenyl ether (BDE-209) and its metabolites in sucking rat pups after prenatal and/or postnatal exposure. Toxicology 283(1): 49-54, 2011

Combined effects of cadmium and decabrominated diphenyl ether on thyroid hormones in rats. Arhiv Za Higijenu Rada i Toksikologiju 63(3): 255-262, 2014

Simulating long-term occupational exposure to decabrominated diphenyl ether using C57BL/6 mice: biodistribution and pathology. Chemosphere 128: 118-124, 2016

Effect of exposure to higher decabrominated diphenyl ether (PBDE-209) on learning and memory functions of BALB/c mice. Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi 28(1): 25-29, 2012

Chronic zebrafish low dose decabrominated diphenyl ether (BDE-209) exposure affected parental gonad development and locomotion in F1 offspring. Ecotoxicology 20(8): 1813-1822, 2012

A national survey of tetrabromobisphenol-A, hexabromocyclododecane and decabrominated diphenyl ether in human milk from China: Occurrence and exposure assessment. Science of the Total Environment 599-600: 237-245, 2017