+ Site Statistics
+ Search Articles
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ PDF Full Text
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Translate
+ Recently Requested

Oxidative stress and skeletal muscle dysfunction are present in healthy smokers

Oxidative stress and skeletal muscle dysfunction are present in healthy smokers

Brazilian Journal of Medical and Biological Research 49(11): E5512

Chronic exposure to cigarette smoke seems to be related to an increase of pro-inflammatory cytokines, oxidative stress and changes in muscular and physical performances of healthy smokers. However, these parameters have not yet been evaluated simultaneously in previous studies. The participants of this study were healthy males divided into two groups: smokers (n=20) and non-smokers (n=20). Inflammation was evaluated by measuring plasma levels of the cytokines IL-10, IL-6 e TNF-α, and of the soluble receptors sTNFR1 and sTNFR2. Oxidative stress was evaluated by determination of thiobarbituric acid reactive substances (TBARS) plasma levels, total antioxidant capacity of plasma and erythrocytes activity of the antioxidant enzymes superoxide dismutase (SOD) and catalase. Muscular performance was evaluated by measuring the peak torque of knee flexors and extensors, and by determining the total work of the knee extensors. Physical performance was assessed by measuring the peak oxygen uptake (VO2 peak), the maximum heart rate (HRmax) and the walking distance in the shuttle walking test. Smokers showed an increase in the levels of the sTNFR1 and TBARS and a decrease in the total antioxidant capacity of plasma, in the catalase activity and in the total work (P<0.05). IL-6, IL-10, sTNFR2, SOD, peak torque, VO2 peak, HRmax and walking distance were similar between groups. Smokers presented increased oxidative stress and skeletal muscle dysfunction, demonstrating that the changes in molecular and muscular parameters occur simultaneously in healthy smokers.

(PDF emailed within 0-6 h: $19.90)

Accession: 058488985

Download citation: RISBibTeXText

PMID: 27783809

DOI: 10.1590/1414-431X20165512

Related references

Skeletal muscle capillarization and oxidative metabolism in healthy smokers. Applied Physiology, Nutrition, and Metabolism 33(6): 1240-1245, 2009

Oxidative stress and skeletal muscle dysfunction with aging. Current Aging Science 4(2): 101-109, 2011

Oxidative stress and peripheral skeletal muscle dysfunction in rats with emphysema. Chinese Medical Journal 123(1): 40-44, 2010

Oxidative stress in cardiac and skeletal muscle dysfunction associated with diabetes mellitus. Journal of Clinical Biochemistry and Nutrition 48(1): 68-71, 2011

Role of Oxidative Stress and Mitochondrial Dysfunction in Skeletal Muscle in Type 2 Diabetic Patients. Current Pharmaceutical Design 22(18): 2650-2656, 2017

Hyperammonaemia-induced skeletal muscle mitochondrial dysfunction results in cataplerosis and oxidative stress. Journal of Physiology 594(24): 7341-7360, 2016

Beneficial effects of exercise on age-related mitochondrial dysfunction and oxidative stress in skeletal muscle. Journal of Physiology 594(18): 5105-5123, 2017

Oxidative stress of myosin contributes to skeletal muscle dysfunction in rats with chronic heart failure. American Journal of Physiology. Heart and Circulatory Physiology 292(2): H1009-H1017, 2006

Mitochondrial dysfunction results from oxidative stress in the skeletal muscle of diet-induced insulin-resistant mice. Journal of Clinical Investigation 118(2): 789-800, 2008

Fructose induces mitochondrial dysfunction and triggers apoptosis in skeletal muscle cells by provoking oxidative stress. Apoptosis 20(7): 930-947, 2016

Cigarette smoke-induced oxidative stress: A role in chronic obstructive pulmonary disease skeletal muscle dysfunction. American Journal of Respiratory and Critical Care Medicine 182(4): 477-488, 2010

Pretreatment with brain natriuretic peptide reduces skeletal muscle mitochondrial dysfunction and oxidative stress after ischemia-reperfusion. Journal of Applied Physiology 114(2): 172-179, 2013

NOD2 activation induces oxidative stress contributing to mitochondrial dysfunction and insulin resistance in skeletal muscle cells. Free Radical Biology and Medicine 89: 158-169, 2016

Skeletal muscle oxidative metabolism in an animal model of pulmonary emphysema: formoterol and skeletal muscle dysfunction. American Journal of Respiratory Cell and Molecular Biology 48(2): 198-203, 2013