+ Site Statistics
References:
54,258,434
Abstracts:
29,560,870
PMIDs:
28,072,757
+ Search Articles
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ PDF Full Text
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Translate
+ Recently Requested

Pencil beam scanning proton therapy vs rotational arc radiation therapy: A treatment planning comparison for postoperative oropharyngeal cancer



Pencil beam scanning proton therapy vs rotational arc radiation therapy: A treatment planning comparison for postoperative oropharyngeal cancer



Medical Dosimetry 42(1): 7-11



Patients diagnosed with head and neck cancer are traditionally treated with photon radiotherapy. Proton therapy is currently being used clinically and may potentially reduce treatment-related toxicities by minimizing the dose to normal organs in the treatment of postoperative oropharyngeal cancer. The finite range of protons has the potential to significantly reduce normal tissue toxicity compared to photon radiotherapy. Seven patients were planned with both proton and photon modalities. The planning goal for both modalities was achieving the prescribed dose to 95% of the planning target volume (PTV). Dose-volume histograms were compared in which all cases met the target coverage goals. Mean doses were significantly lower in the proton plans for the oral cavity (1771cGy photon vs 293cGy proton, p < 0.001), contralateral parotid (1796cGy photon vs 1358 proton, p < 0.001), and the contralateral submandibular gland (3608cGy photon vs 3251cGy proton, p = 0.03). Average total integral dose was 9.1% lower in proton plans. The significant dosimetric sparing seen with proton therapy may lead to reduced side effects such as pain, weight loss, taste changes, and dry mouth. Prospective comparisons of protons vs photons for disease control, toxicity, and patient-reported outcomes are therefore warranted and currently being pursued.

(PDF emailed within 0-6 h: $19.90)

Accession: 058521741

Download citation: RISBibTeXText

PMID: 27839693

DOI: 10.1016/j.meddos.2016.09.004


Related references

Robust Proton Pencil Beam Scanning Treatment Planning for Rectal Cancer Radiation Therapy. International Journal of Radiation Oncology, Biology, Physics 95(1): 208-215, 2016

A comparison of two pencil beam scanning treatment planning systems for proton therapy. Journal of Applied Clinical Medical Physics 19(1): 156-163, 2017

Spot-scanning beam proton therapy vs intensity-modulated radiation therapy for ipsilateral head and neck malignancies: a treatment planning comparison. Medical Dosimetry 38(4): 390-394, 2014

Comparison of Scanning Beam Proton Therapy (SBPT) to Intensity Modulated X-ray Therapy (IMRT) for Postoperative Salvage Treatment of Prostate Cancer Patients. International Journal of Radiation Oncology*biology*physics 84(3): S843-S844, 2012

Spot scanning proton beam therapy for prostate cancer: treatment planning technique and analysis of consequences of rotational and translational alignment errors. International Journal of Radiation Oncology, Biology, Physics 78(2): 428-434, 2010

Pencil Beam Scanning Proton Therapy in the Treatment of Rectal Cancer. International Journal of Radiation Oncology*biology*physics 87(2): S341-S342, 2013

Beam-specific planning target volumes incorporating 4D CT for pencil beam scanning proton therapy of thoracic tumors. Journal of Applied Clinical Medical Physics 16(6): 5678, 2016

Pencil-beam scanning proton therapy for anal cancer: a dosimetric comparison with intensity-modulated radiotherapy. Acta Oncologica 54(8): 1209-1217, 2016

Pencil beam scanning proton therapy for treatment of the retroperitoneum after nephrectomy for Wilms tumor: A dosimetric comparison study. Pediatric Blood and Cancer 64(1): 39-45, 2016

A Novel Method for the Delivery of 3-Dimensional High-Dose Spatially Fractionated Radiation Therapy With Pencil Beam Scanning Proton Therapy: Maximizing the Benefit of the Bragg Peak. International Journal of Radiation Oncology*biology*physics 99(2): S232-S233, 2017

Comparison of proton therapy treatment planning for head tumors with a pencil beam algorithm on dual and single energy CT images. Medical Physics 43(1): 495, 2016

Assessing the radiation-induced second cancer risk in proton therapy for pediatric brain tumors: the impact of employing a patient-specific aperture in pencil beam scanning. Physics in Medicine and Biology 61(1): 12-22, 2016

Pencil Beam Scanning (PBS) Proton Therapy in a Fixed-Beam Room for Treatment of Pediatric Brain Tumors. International Journal of Radiation Oncology*biology*physics 87(2): S592-S593, 2013

Proton therapy posterior beam approach with pencil beam scanning for esophageal cancer : Clinical outcome, dosimetry, and feasibility. Strahlentherapie und Onkologie 192(12): 913-921, 2016

Impact of Spot Size and Beam-Shaping Devices on the Treatment Plan Quality for Pencil Beam Scanning Proton Therapy. International Journal of Radiation Oncology, Biology, Physics 95(1): 190-198, 2016