Pharmaceutical Potential of Synthetic and Natural Pyrrolomycins
Cascioferro, S.; Raimondi, M.V.; Cusimano, M.G.; Raffa, D.; Maggio, B.; Daidone, G.; Schillaci, D.
Molecules 20(12): 21658-21671
ISSN/ISBN: 1420-3049 PMID: 26690095 DOI: 10.3390/molecules201219797
The emergence of antibiotic resistance is currently considered one of the most important global health problem. The continuous onset of multidrug-resistant Gram-positive and Gram-negative bacterial strains limits the clinical efficacy of most of the marketed antibiotics. Therefore, there is an urgent need for new antibiotics. Pyrrolomycins are a class of biologically active compounds that exhibit a broad spectrum of biological activities, including antibacterial, antifungal, anthelmintic, antiproliferative, insecticidal, and acaricidal activities. In this review we focus on the antibacterial activity and antibiofilm activity of pyrrolomycins against Gram-positive and Gram-negative pathogens. Their efficacy, combined in some cases with a low toxicity, confers to these molecules a great potential for the development of new antimicrobial agents to face the antibiotic crisis.