+ Site Statistics
References:
54,258,434
Abstracts:
29,560,870
PMIDs:
28,072,757
+ Search Articles
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ PDF Full Text
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Translate
+ Recently Requested

Plant-based vaccines for animals and humans: recent advances in technology and clinical trials



Plant-based vaccines for animals and humans: recent advances in technology and clinical trials



Therapeutic Advances in Vaccines 3(5-6): 139-154



It has been about 30 years since the first plant engineering technology was established. Although the concept of plant-based pharmaceuticals or vaccines motivates us to develop practicable commercial products using plant engineering, there are some difficulties in reaching the final goal: to manufacture an approved product. At present, the only plant-made vaccine approved by the United States Department of Agriculture is a Newcastle disease vaccine for poultry that is produced in suspension-cultured tobacco cells. The progress toward commercialization of plant-based vaccines takes much effort and time, but several candidate vaccines for use in humans and animals are in clinical trials. This review discusses plant engineering technologies and regulations relevant to the development of plant-based vaccines and provides an overview of human and animal vaccines currently under clinical trials.

(PDF emailed within 0-6 h: $19.90)

Accession: 058561460

Download citation: RISBibTeXText

PMID: 26668752

DOI: 10.1177/2051013615613272


Related references

M2-based influenza vaccines: recent advances and clinical potential. Expert Review of Vaccines 16(2): 123-136, 2016

Gene-based vaccines: recent technical and clinical advances. Trends in Molecular Medicine 12(5): 216-222, 2006

Recent advances in the use of DNA vaccines for the treatment of diseases of farmed animals. Advanced Drug Delivery Reviews 43(1): 13-28, 2000

Carcinoembryonic antigen (CEA)-based cancer vaccines: recent patents and antitumor effects from experimental models to clinical trials. Recent Patents on Anti-Cancer Drug Discovery 7(3): 265-296, 2013

Recent Advances in Nucleic Acid-Based Delivery: From Bench to Clinical Trials in Genetic Diseases. Journal of Biomedical Nanotechnology 12(5): 841-862, 2016

Prospects for subunit vaccines: Technology advances resulting in efficacious antigens requires matching advances in early clinical trial investment. Human Vaccines and Immunotherapeutics 12(12): 3103-3106, 2016

Plant-made vaccines for humans and animals. Plant Biotechnology Journal 8(5): 620-637, 2010

Stem cell-based therapies for multiple sclerosis: recent advances in animal models and human clinical trials. Regenerative Medicine 9(2): 129-132, 2015

Recent advances concerning the mechanisms of apoptosis and the emergence of protozooses in humans and animals. Revista Romana De Medicina Veterinara: 3, 11-17, 2008

Consciousness in humans and non-human animals: recent advances and future directions. Frontiers in Psychology 4: 625, 2013

Recent advances in the hormonal regulation of calcium and phosphorus in adult animals and humans. Unknown, 1983

New advances in clinical trials of cancer vaccines. Ai Zheng 25(8): 1059-1062, 2006

Recent advances in the development of HIV-1 Tat-based vaccines. Current HIV Research 2(4): 357-376, 2004

Recent advances in carbohydrate-based vaccines. Current Opinion in Chemical Biology 13(3): 354-359, 2009

Recent advances and safety issues of transgenic plant-derived vaccines. Applied Microbiology and Biotechnology 97(7): 2817-2840, 2013