+ Site Statistics
+ Search Articles
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ PDF Full Text
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Translate
+ Recently Requested

Polymerization Induced Self-Assembly of Alginate Based Amphiphilic Graft Copolymers Synthesized by Single Electron Transfer Living Radical Polymerization

Polymerization Induced Self-Assembly of Alginate Based Amphiphilic Graft Copolymers Synthesized by Single Electron Transfer Living Radical Polymerization

Biomacromolecules 16(7): 2040-2048

Alginate-based amphiphilic graft copolymers were synthesized by single electron transfer living radical polymerization (SET-LRP), forming stable micelles during polymerization induced self-assembly (PISA). First, alginate macroinitiator was prepared by partial depolymerization of native alginate, solubility modification and attachment of initiator. Depolymerized low molecular weight alginate (∼12 000 g/mol) was modified with tetrabutylammonium, enabling miscibility in anhydrous organic solvents, followed by initiator attachment via esterification yielding a macroinitiator with a degree of substitution of 0.02, or 1-2 initiator groups per alginate chain. Then, methyl methacrylate was polymerized from the alginate macroinitiator in mixtures of water and methanol, forming poly(methyl methacrylate) grafts, prior to self-assembly, of ∼75 000 g/mol and polydispersity of 1.2. PISA of the amphiphilic graft-copolymer resulted in the formation of micelles with diameters of 50-300 nm characterized by light scattering and electron microscopy. As the first reported case of LRP from alginate, this work introduces a synthetic route to a preparation of alginate-based hybrid polymers with a precise macromolecular architecture and desired functionalities. The intended application is the preparation of micelles for drug delivery; however, LRP from alginate can also be applied in the field of biomaterials to the improvement of alginate-based hydrogel systems such as nano- and microhydrogel particles, islet encapsulation materials, hydrogel implants, and topical applications. Such modified alginates can also improve the function and application of native alginates in food and agricultural applications.

(PDF emailed within 0-6 h: $19.90)

Accession: 058571124

Download citation: RISBibTeXText

PMID: 26068280

DOI: 10.1021/acs.biomac.5b00470

Related references

Synthesis of AB diblock copolymers by atom-transfer radical polymerization (ATRP) and living polymerization of alpha-amino acid-N-carboxyanhydrides. Macromolecular Bioscience 4(6): 566-569, 2004

New Strategy Targeting Well-Defined Polymethylene-block-Polystyrene Copolymers: The Combination of Living Polymerization of Ylides and Atom Transfer Radical Polymerization. Macromolecular Rapid Communications 30(7): 532-538, 2009

Synthesis of block copolymers by combination of atom transfer radical polymerization and visible light-induced free radical promoted cationic polymerization. Macromolecular Rapid Communications 33(4): 309-313, 2013

New hyaluronic acid based brush copolymers synthesized by atom transfer radical polymerization. Carbohydrate Polymers 92(2): 1054-1063, 2013

Hemicellulose-based multifunctional macroinitiator for single-electron-transfer mediated living radical polymerization. Biomacromolecules 12(1): 253-259, 2011

Integration of CuAAC Polymerization and Controlled Radical Polymerization into Electron Transfer Mediated "Click-Radical" Concurrent Polymerization. Macromolecular Rapid Communications 38(6), 2017

Synthesis, characterization, and micellization of an epoxy-based amphiphilic diblock copolymer of e-caprolactone and glycidyl methacrylate by enzymatic ring-opening polymerization and atom transfer radical polymerization. Journal of polymer science Part A Polymer chemistry15 45(22): 5037-5049, 2007

Synthesis of Well-defined Amphiphilic Block Copolymers by Organotellurium-Mediated Living Radical Polymerization (TERP). Macromolecular Rapid Communications 32(19): 1576-1582, 2017

Degradable copolymers with incorporated ester groups by radical ring-opening polymerization using atom transfer radical polymerization. Polimery 62(4): 262-271, 2017

Single-electron transfer and single-electron transfer degenerative chain transfer living radical polymerization. Chemical Reviews 109(11): 5069-5119, 2010

Uniform PEO star polymers synthesized in water via free radical polymerization or atom transfer radical polymerization. Macromolecular Rapid Communications 32(1): 74-81, 2011

Synthesis of perfectly bifunctional polyacrylates by single-electron-transfer living radical polymerization. Journal of polymer science Part A Polymer chemistry15 45(20): 4684-4695, 2007

Single-Electron Transfer Living Radical Polymerization Platform to Practice, Develop, and Invent. Biomacromolecules 18(10): 2981-3008, 2017

Recent Developments in the Synthesis of Biomacromolecules and their Conjugates by Single Electron Transfer-Living Radical Polymerization. Biomacromolecules 18(4): 1039-1063, 2017

Photo-Controlled Polymerization-Induced Self-Assembly (Photo-PISA): A Novel Strategy Using In Situ Bromine-Iodine Transformation Living Radical Polymerization. Macromolecular Rapid Communications 2018: E1800327, 2018