+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Preliminary in vitro antiplasmodial activity of Aristolochia griffithii and Thalictrum foliolosum DC extracts against malaria parasite Plasmodium falciparum



Preliminary in vitro antiplasmodial activity of Aristolochia griffithii and Thalictrum foliolosum DC extracts against malaria parasite Plasmodium falciparum



Bmc Research Notes 9: 51



Resistance development in human malaria parasites against commonly used antimalarial drugs has necessitated the scientific exploration of traditionally used antimalarial plants. Plant derivatives have been used for curing malaria historically. The present study involves in vitro evaluation of two medicinally important plants Aristolochia griffithii and Thalictrum foliolosum DC used in antimalarial chemotherapy by the tribes of northeast India. Chloroform, ethyl acetate and n-butanol extracts of Aristolochia griffithii and Thalictrum foliolosum DC were evaluated in vitro against chloroquine sensitive (SS) and chloroquine resistance strains (RS) of P. falciparum. The tests were conducted following WHO standard method and the inhibition of parasite (IC50) was calculated. In A. griffithii, the IC50 value for ethyl acetate extracts against SS was 6.2 ± 0.02 μg/ml and found to be lower than chloroform extracts, which exhibited an IC50 value of 14.1 ± 0.1 μg/ml (t = 191.1; p < 0.0001). The IC50 values of both chloroform and ethyl acetate extracts for RS were higher as compared to the SS (p < 0.0001). In T. foliolosum DC the IC50 concentration of chloroform extracts for SS and RS were 0.5 ± 0.0 and 1.1 ± 0.0 μg/ml respectively (t = 54.2; p < 0.0001). The present findings, although preliminary, but scientifically demonstrate that identification and isolation of active compounds of these two plant materials and testing against different Plasmodium species could lead to the development of potential antimalarial drugs for future.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 058603875

Download citation: RISBibTeXText

PMID: 26821745

DOI: 10.1186/s13104-016-1862-4


Related references

4-Thiophenoxy-2-trichloromethyquinazolines display in vitro selective antiplasmodial activity against the human malaria parasite Plasmodium falciparum. Bioorganic and Medicinal Chemistry Letters 21(19): 6003-6006, 2011

Targeting the human malaria parasite Plasmodium falciparum: in vitro identification of a new antiplasmodial hit in 4-phenoxy-2-trichloromethylquinazoline series. European Journal of Medicinal Chemistry 46(9): 4184-4191, 2011

In vitro antiplasmodial activity of ethanolic extracts of seaweed macroalgae against Plasmodium falciparum. Parasitology Research 108(6): 1411-1416, 2011

Antiplasmodial activity of extracts of Tridax procumbens and Phyllanthus amarus in in vitro Plasmodium falciparum culture systems. Ghana Medical Journal 45(4): 143-150, 2011

In Vitro Assessment of Antiplasmodial Activity and Cytotoxicity of Polyalthia longifolia Leaf Extracts on Plasmodium falciparum Strain NF54. Malaria Research and Treatment 2019: 6976298, 2019

The Novel Oxygenated Chalcone, 2,4-Dimethoxy-4-Butoxychalcone, Exhibits Potent Activity against Human Malaria Parasite Plasmodium falciparum in vitro and Rodent Parasites Plasmodium berghei and Plasmodium yoelii in vivo. The Journal of Infectious Diseases 176(5): 1327-1333, 1997

The novel oxygenated chalcone, 2,4-dimethoxy-4'-butoxychalcone, exhibits potent activity against human malaria parasite Plasmodium falciparum in vitro and rodent parasites Plasmodium berghei and Plasmodium yoelii in vivo. Journal of Infectious Diseases 176(5): 1327-1333, 1997

In vitro antiplasmodial activity of ethanolic extracts of mangrove plants from South East coast of India against chloroquine-sensitive Plasmodium falciparum. Parasitology Research 108(4): 873-878, 2011

In vitro activity of riboflavin against the human malaria parasite Plasmodium falciparum. Antimicrobial Agents and ChemoTherapy 44(1): 88-96, 2000

In Vitro Activity of Riboflavin against the Human Malaria Parasite Plasmodium falciparum. Antimicrobial Agents and Chemotherapy 44(1): 88-96, 2000

Antiplasmodial activity of botanical extracts against Plasmodium falciparum. Parasitology Research 108(5): 1099-1109, 2011

In vitro antiplasmodial effect of ethanolic extracts of coastal medicinal plants along Palk Strait against Plasmodium falciparum. Asian Pacific Journal of Tropical Biomedicine 2(5): 364-367, 2012

In vitro antiplasmodial effect of ethanolic extracts of traditional medicinal plant Ocimum species against Plasmodium falciparum. Asian Pacific Journal of Tropical Medicine 5(2): 103-106, 2012

Circumsporozoite protein gene from Plasmodium reichenowi, a chimpanzee malaria parasite evolutionarily related to the human malaria parasite Plasmodium falciparum. Journal of Biological Chemistry 266(11): 6686-6689, 1991

Proteomic analysis of zygote and ookinete stages of the avian malaria parasite Plasmodium gallinaceum delineates the homologous proteomes of the lethal human malaria parasite Plasmodium falciparum. Proteomics 8(12): 2492-2499, 2008