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Preparation technology optimization of xiaozhong cataplasm by central composite design-response surface method and preliminary clinical effect evaluation



Preparation technology optimization of xiaozhong cataplasm by central composite design-response surface method and preliminary clinical effect evaluation



Zhong Yao Cai 37(9): 1663-1667



To optimize the preparation technology of Xiaozhong Cataplasm and to evaluate its preliminary clinical effect. The viscosity, residue and appearance were selected as evaluation indexes. The central composite design-response surface methodology was applied to optimize the amounts of Skeleton material, tackifier and crosslinking agent. Clinical effect of Xiaozhong Cataplasm was observed. The optimal formulation was HQ841: PVP k120: PVPP: aluminium glycinate: water: glycerin: ethanol = 4:3:2:0.15: 60:25:10. The effective rate of the cataplasm was 97.22% and 91.67% had marked effect. Prepared by the optimal preparation technology, the cataplasm has the moderate viscosity and little residue with good clinical effect.

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Accession: 058609026

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PMID: 25857169


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