+ Site Statistics
+ Search Articles
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ PDF Full Text
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Translate
+ Recently Requested

Preparation, Physicochemical Characterization and Anti-fungal Evaluation of Nystatin-Loaded PLGA-Glucosamine Nanoparticles

Preparation, Physicochemical Characterization and Anti-fungal Evaluation of Nystatin-Loaded PLGA-Glucosamine Nanoparticles

Pharmaceutical Research 34(2): 301-309

Nystatin loaded PLGA and PLGA-Glucosamine nanoparticles were formulated. PLGA were functionalized with Glucosamine (PLGA-GlcN) to enhance the adhesion of nanoparticles to Candida Albicans (C.albicans) cell walls. Quasi-emulsion solvent diffusion method was employed using PLGA and PLGA-GlcN with various drug-polymer ratios for the preparation of nanoparticles. The nanoparticles were evaluated for size, zeta potential, polydispersity index, drug crystallinity, loading efficiency and release properties. DSC, SEM, XRPD, 1H-NMR, and FT-IR were performed to analyze the physicochemical properties of the nanoparticles. Antifungal activity of the nanoparticles was evaluated by determination of MICs against C.albicans. The spectra of 1H-NMR and FT-IR analysis ensured GlcN functionalization on PLGA nanoparticles. SEM characterization confirmed that particles were in the nanosize range and the particle size for PLGA and PLGA-GlcN nanoparticles were in the range of 108.63 ± 4.5 to 168.8 ± 5.65 nm and 208.76 ± 16.85 nm, respectively. DSC and XRPD analysis ensured reduction of the drug crystallinity in the nanoparticles. PLGA-GlcN nanoparticles exhibit higher antifungal activity than PLGA nanoparticles. PLGA-GlcN nanoparticles showed more antifungal activity with appropriate physicochemical properties than pure Nystatin and PLGA nanoparticles.

(PDF emailed within 0-6 h: $19.90)

Accession: 058609059

Download citation: RISBibTeXText

PMID: 27928646

DOI: 10.1007/s11095-016-2062-6

Related references

Paclitaxel-loaded PLGA nanoparticles: Preparation, physicochemical characterization and in vitro anti-tumoral activity. Journal of Controlled Release 83(2): 273-286, 4 October, 2002

Evaluation of β-Sitosterol Loaded PLGA and PEG-PLA Nanoparticles for Effective Treatment of Breast Cancer: Preparation, Physicochemical Characterization, and Antitumor Activity. Pharmaceutics 10(4), 2018

Doxorubicin-loaded PLGA nanoparticles by nanoprecipitation: preparation, characterization and in vitro evaluation. Nanomedicine 2(2): 219-232, 2007

Preparation and characterization of monensin loaded PLGA nanoparticles: in vitro anti-malarial activity against Plasmodium falciparum. Journal of Biomedical Nanotechnology 8(1): 172-181, 2012

Preparation, characterization and evaluation of targeting potential of amphotericin B-loaded engineered PLGA nanoparticles. Pharmaceutical Research 26(12): 2588-2598, 2010

Preparation, Characterization and In Vivo Evaluation of pH-sensitive Oral Insulin-Loaded PLGA Nanoparticles. 2011

Preparation, characterization and immunological evaluation: canine parvovirus synthetic peptide loaded PLGA nanoparticles. Journal of Biomedical Science 22: 89, 2016

Development of bicalutamide-loaded PLGA nanoparticles: preparation, characterization and in-vitro evaluation for the treatment of prostate cancer. Artificial Cells, Nanomedicine, and Biotechnology 45(5): 944-954, 2016

Development and physicochemical characterization of copper complexes-loaded PLGA nanoparticles. International Journal of Pharmaceutics 379(2): 226-234, 2010

Praziquantel-loaded PLGA nanoparticles: preparation and characterization. Journal of Microencapsulation 22(1): 13-24, 2005

Preparation and physicochemical characterization of naproxen-PLGA nanoparticles. Colloids and Surfaces. B, Biointerfaces 81(2): 498-502, 2011

Preparation, characterization, and anticancer efficacy of evodiamine-loaded PLGA nanoparticles. Drug Delivery 23(3): 908-916, 2016

Preparation and in vitro evaluation of thienorphine-loaded PLGA nanoparticles. Drug Delivery 23(3): 787-793, 2016

Preparation and characterization of insulin-loaded bioadhesive PLGA nanoparticles for oral administration. European Journal of Pharmaceutical Sciences 45(5): 632-638, 2012

Preparation and Antibacterial Activity Evaluation of 18-β-glycyrrhetinic Acid Loaded PLGA Nanoparticles. Iranian Journal of Pharmaceutical Research 14(2): 373-383, 2015