+ Site Statistics
+ Search Articles
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on Google+Follow on Google+
Follow on LinkedInFollow on LinkedIn

+ Translate

Prescription and indication trends of antidepressant drugs in the Netherlands between 1996 and 2012: a dynamic population-based study

Prescription and indication trends of antidepressant drugs in the Netherlands between 1996 and 2012: a dynamic population-based study

European Journal of Clinical Pharmacology 71(3): 369-375

Antidepressant drug use increases worldwide. It is pivotal to closely monitor the use of antidepressants and to determine in what subpopulations the rise is most substantial. In a Dutch primary care database, we aimed to investigate the (sex- and age-specific) prevalence and incidence of antidepressant prescription and to monitor the indication of incident prescriptions over a 17-year period (1996-2012). This study, embedded in the Integrated Primary Care Information database, included all patients aged 10 years or older. Per calendar year, prevalence and incidence of antidepressant drug prescription were calculated by drug class (tricyclic antidepressants, selective serotonin reuptake inhibitors (SSRIs), and others), sex, and age. The indication of incident prescriptions (e.g., depression, anxiety, sleep disorders, and neuropathic pain) was determined based on the International Classification of Primary Care codes. In total, 1.49 million patients were included. For all antidepressants together, the prevalence increased over time. However, incident prescription of specific SSRIs decreased from 2000 onward. During the study period, incidence and prevalence were higher in older and female patients. The increase in prevalence and the decrease in incidence were more pronounced in females than that in males. Furthermore, antidepressants were increasingly prescribed for indications such as neuropathic pain and sleep disorders. In Dutch primary care, prevalent prescription of antidepressants continued to increase, but incident prescription of particular SSRIs decreased from 2000 onward. In later years, antidepressants were less frequently prescribed for depression-related indications in incident users.

(PDF same-day service: $19.90)

Accession: 058610231

Download citation: RISBibTeXText

PMID: 25560052

DOI: 10.1007/s00228-014-1803-x

Related references

A population-based study of antipsychotic prescription trends in children and adolescents in British Columbia, from 1996 to 2011. Canadian Journal of Psychiatry. Revue Canadienne de Psychiatrie 58(6): 361-369, 2013

Trends in the prescription of antidiabetic medications from 2009 to 2012 in a general practice of Southern Italy: a population-based study. Diabetes Research and Clinical Practice 108(1): 157-163, 2015

Suicide and self-harm trends in recent immigrant youth in Ontario, 1996-2012: a population-based longitudinal cohort study. Bmj Open 7(9): E014863-E014863, 2017

Trends in incident use of benzodiazepines and Z-drugs in France from 2006 to 2012: a population-based study. Pharmacoepidemiology and Drug Safety (): -, 2016

Differences in prescription rates and odds ratios of antidepressant drugs in relation to individual hormonal contraceptives: a nationwide population-based study with age-specific analyses. European Journal of Contraception & Reproductive Health Care 17(2): 106-118, 2012

Trends in incidence, primary treatment and survival in chronic myelomonocytic leukaemia: a population-based study of 1359 patients diagnosed in the Netherlands from 1989 to 2012. British Journal of Haematology 171(3): 436-439, 2016

Prescription patterns for psychotropic drugs in cancer patients; a large population study in the Netherlands. Psycho-Oncology 22(4): 762-767, 2013

Relationship between antidepressant prescription and breast cancer: a population based study in Taiwan. Psycho-Oncology 25(7): 803-807, 2015

Prescription and predictors of post-stroke antidepressant treatment: A population-based study. Acta Neurologica Scandinavica, 2018

Prescription of potentially inappropriate medication in Korean older adults based on 2012 Beers Criteria: a cross-sectional population based study. Bmc Geriatrics 16(): 118-118, 2016

Trends in boxed warnings and withdrawals for novel therapeutic drugs, 1996 through 2012. JAMA Internal Medicine 174(10): 1704-1705, 2015

Cancer risk in HIV-infected people in the USA from 1996 to 2012: a population-based, registry-linkage study. Lancet. HIV 4(11): E495-E504, 2017

Incidence of microscopic colitis in the Netherlands. A nationwide population-based study from 2000 to 2012. Digestive and Liver Disease 47(1): 30-36, 2015

Term perinatal mortality audit in the Netherlands 2010-2012: a population-based cohort study. Bmj Open 4(10): E005652-E005652, 2015

Risk of cardiovascular events and pulmonary hypertension following splenectomy - a Danish population-based cohort study from 1996-2012. Haematologica 102(8): 1333-1341, 2017