+ Site Statistics
+ Search Articles
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on Google+Follow on Google+
Follow on LinkedInFollow on LinkedIn

+ Translate

Prescription and indication trends of antidepressant drugs in the Netherlands between 1996 and 2012: a dynamic population-based study

, : Prescription and indication trends of antidepressant drugs in the Netherlands between 1996 and 2012: a dynamic population-based study. European Journal of Clinical Pharmacology 71(3): 369-375

Antidepressant drug use increases worldwide. It is pivotal to closely monitor the use of antidepressants and to determine in what subpopulations the rise is most substantial. In a Dutch primary care database, we aimed to investigate the (sex- and age-specific) prevalence and incidence of antidepressant prescription and to monitor the indication of incident prescriptions over a 17-year period (1996-2012). This study, embedded in the Integrated Primary Care Information database, included all patients aged 10 years or older. Per calendar year, prevalence and incidence of antidepressant drug prescription were calculated by drug class (tricyclic antidepressants, selective serotonin reuptake inhibitors (SSRIs), and others), sex, and age. The indication of incident prescriptions (e.g., depression, anxiety, sleep disorders, and neuropathic pain) was determined based on the International Classification of Primary Care codes. In total, 1.49 million patients were included. For all antidepressants together, the prevalence increased over time. However, incident prescription of specific SSRIs decreased from 2000 onward. During the study period, incidence and prevalence were higher in older and female patients. The increase in prevalence and the decrease in incidence were more pronounced in females than that in males. Furthermore, antidepressants were increasingly prescribed for indications such as neuropathic pain and sleep disorders. In Dutch primary care, prevalent prescription of antidepressants continued to increase, but incident prescription of particular SSRIs decreased from 2000 onward. In later years, antidepressants were less frequently prescribed for depression-related indications in incident users.

Accession: 058610231

PMID: 25560052

DOI: 10.1007/s00228-014-1803-x

Submit PDF Full Text: Here

Submit PDF Full Text

No spam - Every submission is manually reviewed

Due to poor quality, we do not accept files from Researchgate

Submitted PDF Full Texts will always be free for everyone
(We only charge for PDFs that we need to acquire)

Select a PDF file:

Related references

Rafaniello, C.; Arcoraci, V.; Ferrajolo, C.; Sportiello, L.; Sullo, M.Giuseppa.; Giorgianni, F.; Trifirò, G.; Tari, M.; Caputi, A.P.; Rossi, F.; Esposito, K.; Giugliano, D.; Capuano, A., 2015: Trends in the prescription of antidiabetic medications from 2009 to 2012 in a general practice of Southern Italy: a population-based study. To assess the prescribing pattern of antidiabetic drugs (AD) in a general practice of Southern Italy from 2009 to 2012, with focus on behaviour prescribing changes. This retrospective, drug utilization study was conducted using administrative data...

Ronsley, R.; Scott, D.; Warburton, W.P.; Hamdi, R.D.; Louie, D.Clare.; Davidson, J.; Panagiotopoulos, C., 2013: A population-based study of antipsychotic prescription trends in children and adolescents in British Columbia, from 1996 to 2011. <b>Objectifs :</b> Établir les taux de prévalence des prescriptions d’antipsychotiques (AP) à des enfants et des adolescents de 18 ans et moins en Colombie-Britannique (C.-B.) de 1996 à 2011 selon l’âge, le sexe, le type d’A...

Bénard-Laribière, A.; Noize, P.; Pambrun, E.; Bazin, F.; Verdoux, Hélène.; Tournier, M.; Bégaud, B.; Pariente, A., 2016: Trends in incident use of benzodiazepines and Z-drugs in France from 2006 to 2012: a population-based study. To study trends in incident use of benzodiazepines in France between 2006 and 2012. A cross-sectional study repeated yearly was conducted using data from the French national healthcare insurance system. New benzodiazepine users were defined as use...

Lindberg, M.; Foldemo, A.; Josefsson, A.; Wiréhn, A-Britt., 2012: Differences in prescription rates and odds ratios of antidepressant drugs in relation to individual hormonal contraceptives: a nationwide population-based study with age-specific analyses. To examine, among young women, the association of individual hormonal contraceptives, within two broad groupings, with antidepressant therapy. In a nationwide register-based study, we examined the prescription rates of antidepressant drugs in rela...

Dinmohamed, A.G.; Brink, M.; Visser, O.; Sonneveld, P.; van de Loosdrecht, A.A.; Jongen-Lavrencic, M.; de Greef, G.E., 2016: Trends in incidence, primary treatment and survival in chronic myelomonocytic leukaemia: a population-based study of 1359 patients diagnosed in the Netherlands from 1989 to 2012. British Journal of Haematology 171(3): 436-439

Ng, C.Guan.; Boks, M.Pm.; Smeets, H.Matthias.; Zainal, N.Zuraida.; de Wit, N.J., 2013: Prescription patterns for psychotropic drugs in cancer patients; a large population study in the Netherlands. Psychotropic drugs are commonly prescribed for various psychological complaints in cancer patients. We aim to examine the prescription pattern in cancer patients of three common psychotropic drugs: benzodiazepine, antidepressant and antipsychotic....

Chen, V.Chin-Hung.; Liao, Y-To.; Yeh, D-Cherng.; Tseng, H-Chun.; Stewart, R.; Lee, C.Tzu-Chi., 2015: Relationship between antidepressant prescription and breast cancer: a population based study in Taiwan. To investigate the association between antidepressant prescription and breast cancer. The National Health Research Institute in Taiwan provided a database of 1 000 000 random subjects for this study. We identified 14 737 new antidepressant fema...

Nam, Y-Seon.; Han, J.Soo.; Kim, J.Young.; Bae, W.Kyung.; Lee, K., 2016: Prescription of potentially inappropriate medication in Korean older adults based on 2012 Beers Criteria: a cross-sectional population based study. A high number of elderly people with multiple comorbidities are exposed to the risk of polypharmacy and prescription of potentially inappropriate medication (PIM). The purpose of this study was to determine the prevalence and patterns of PIM presc...

Cheng, C.M.; Shin, J.; Guglielmo, B.Joseph., 2015: Trends in boxed warnings and withdrawals for novel therapeutic drugs, 1996 through 2012. JAMA Internal Medicine 174(10): 1704-1705

Verhaegh, B.P.M.; Jonkers, D.M.A.E.; Driessen, A.; Zeegers, M.P.; Keszthelyi, D.; Masclee, A.A.M.; Pierik, M.J., 2015: Incidence of microscopic colitis in the Netherlands. A nationwide population-based study from 2000 to 2012. Incidence rates of microscopic colitis are mainly based on regional data from a limited number of countries. To evaluate geographical differences and changes over time, more nationwide incidence rates are needed. The aim of this retrospective stud...