+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Prevalence, incidence and prognosis of chronic kidney disease classified according to current guidelines: a large retrospective cohort study of rheumatoid arthritis patients



Prevalence, incidence and prognosis of chronic kidney disease classified according to current guidelines: a large retrospective cohort study of rheumatoid arthritis patients



Nephrology, Dialysis, Transplantation 32(12): 2035-2042



The prevalence, incidence and prognosis of chronic kidney disease (CKD) have not been fully understood in rheumatoid arthritis (RA) patients. A retrospective cohort study was performed in 1077 RA patients from July 2004 to June 2014. CKD was defined as either proteinuria ≥1+ or estimated glomerular filtration rate (eGFR) <60 mL/min/1.73 m2 or both, according to the current CKD classification with risk categories for future death, end-stage renal disease and cardiovascular disease. The cumulative incidence of mortality and CKD was analyzed using the Kaplan-Meier method. The association of each outcome with known risk factors was analyzed using multivariate Cox proportional hazards regression models. Hazard ratios (HRs) with 95% confidence intervals (CIs) for mortality and incidence of CKD were calculated for estimation. The mean follow-up period was 51.5 ± 39.6 months, and the cumulative mortality was 20.6% over 10 years. The prevalence of any CKD was 24.5% at enrollment. Preexisting CKD was significantly associated with future death [HR 1.64 (95% CI 1.05-2.57)]. This association was the most robust in very-high-risk CKD [HR 4.76 (95% CI 2.24-9.51)]. The cumulative incidence of CKD over time was 59.5% in 813 patients who did not have prior CKD. Aside from the commonly known risk factors, the use of prednisolone and nonsteroidal anti-inflammatory drugs increased the likelihood of death [HR 1.75 (95% CI 1.11-2.79)] and incident CKD [HR 1.44 (95% CI 1.13-1.86)]. The incidence of CKD increases over time among RA patients and prevalent CKD may be an insidious risk factor linked to increased mortality in RA patients.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 058620008

Download citation: RISBibTeXText

PMID: 27638912

DOI: 10.1093/ndt/gfw315


Related references

Prevalence and mortality of chronic kidney disease in lymphoma patients: A large retrospective cohort study. Medicine 97(2): E9615, 2018

Prevalence and correlates of gout in a large cohort of patients with chronic kidney disease: the German Chronic Kidney Disease (GCKD) study. Nephrology, Dialysis, Transplantation 30(4): 613-621, 2016

Physical activity is associated with decreased incidence of chronic kidney disease in type 2 diabetes patients: a retrospective cohort study in Taiwan. Primary Care Diabetes 8(4): 315-321, 2015

Short-term prognosis of emergently hospitalized dialysis-independent chronic kidney disease patients: A nationwide retrospective cohort study in Japan. Plos One 13(11): E0208258, 2018

Prevalence, incidence, indication, and choice of antidepressants in patients with and without chronic kidney disease: a matched cohort study in UK Clinical Practice Research Datalink. Pharmacoepidemiology and Drug Safety 26(7): 792-801, 2017

Prevalence and risk factors for cardiovascular disease among chronic kidney disease patients: results from the Chinese cohort study of chronic kidney disease (C-STRIDE). Bmc Nephrology 18(1): 23, 2017

The Prevalence and Management of Anemia in Chronic Kidney Disease Patients: Result from the KoreaN Cohort Study for Outcomes in Patients With Chronic Kidney Disease (KNOW-CKD). Journal of Korean Medical Science 32(2): 249-256, 2017

Relevance of New Definitions to Incidence and Prognosis of Acute Kidney Injury in Hospitalized Patients with Cirrhosis: A Retrospective Population-Based Cohort Study. Plos One 11(8): E0160394, 2017

Incidence, prevalence, etiology, and prognosis of first-time chronic pancreatitis in young patients: a nationwide cohort study. Digestive Diseases and Sciences 55(10): 2988-2998, 2010

A comparison of the malignancy incidence among patients with psoriatic arthritis and patients with rheumatoid arthritis in a large US cohort. Arthritis and Rheumatology 66(6): 1472-1481, 2014

Coagulation profile in patients with chronic kidney disease before and after kidney transplantation: A retrospective cohort study. Clinical Transplantation 31(9), 2017

Increased Risk of Chronic Kidney Disease in Rheumatoid Arthritis Associated with Cardiovascular Complications - A National Population-Based Cohort Study. Plos One 10(9): E0136508, 2016

Prevalence and prognosis of mild anemia in non-dialysis chronic kidney disease: a prospective cohort study in outpatient renal clinics. American Journal of Nephrology 32(6): 533-540, 2011

Association of anthropometric measures with kidney disease progression and mortality: a retrospective cohort study of pre-dialysis chronic kidney disease patients referred to a specialist renal service. Bmc Nephrology 17(1): 74, 2017

Observational multicenter study to evaluate the prevalence and prognosis of subclinical atheromatosis in a Spanish chronic kidney disease cohort: baseline data from the NEFRONA study. Bmc Nephrology 15: 168, 2015