+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Preventing cardiovascular disease in patients with diabetes: use of aspirin for primary prevention



Preventing cardiovascular disease in patients with diabetes: use of aspirin for primary prevention



Current Cardiology Reports 17(3): 566



Diabetics are at high risk for atherosclerotic cardiovascular disease (ASCVD) and are considered a coronary heart disease risk equivalent. The utility of aspirin in primary prevention of ASCVD in diabetic patients has been widely studied and is still debated. Overall, the current evidence suggests a modest benefit for reduction in ASCVD events with the greatest benefit among those with higher baseline risk, but at the cost of increased risk of gastrointestinal bleeding. Diabetic patients at higher risk (with 10-year ASCVD risk >10 %) are generally recommended for aspirin therapy if bleeding risk is felt to be low. A patient-provider discussion is recommended before prescribing aspirin therapy. Novel markers such as coronary artery calcium scores and high-sensitivity C-reactive protein may help refine ASCVD risk prediction and guide utility for aspirin therapy. This article will review the literature for the most up-to-date studies evaluating aspirin therapy for primary prevention of ASCVD in patients with diabetes.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 058620554

Download citation: RISBibTeXText

PMID: 25676828

DOI: 10.1007/s11886-015-0566-z


Related references

Aspirin for primary prevention of cardiovascular disease in patients with diabetes: A meta-analysis. Diabetes Research and Clinical Practice 120: 31-39, 2016

Primum non nocere: An updated meta-analysis on aspirin use in primary prevention of cardiovascular disease in patients with diabetes. European Journal of Preventive Cardiology 2019: 2047487319826439, 2019

Aspirin for the primary prevention of cardiovascular events in patients with peripheral artery disease or diabetes mellitus. Analyses from the JPAD, POPADAD and AAA trials. Thrombosis and Haemostasis 104(6): 1085-1088, 2011

Aspirin for primary prevention of cardiovascular disease in diabetes. Journal of Diabetes Investigation 2019, 2019

Primary and secondary prevention of cardiovascular disease in diabetes with aspirin. Diabetes and Vascular Disease Research 9(4): 243-244, 2013

Should aspirin be used for the primary prevention of cardiovascular disease in people with diabetes?. Medical Journal of Australia 190(11): 614-615, 2009

Aspirin for primary prevention of cardiovascular disease events in diabetes: the balancing act?. Journal of the Royal College of Physicians of Edinburgh 48(4): 332-333, 2018

Aspirin therapy and primary prevention of cardiovascular disease in diabetes mellitus. Diabetes, Obesity and Metabolism 11(11): 997-1000, 2011

Primary Prevention of Cardiovascular Events With Aspirin in Patients With Diabetes. Diabetes Spectrum 24(1): 47-49, 2011

Role of aspirin in the primary prevention of cardiovascular disease in diabetes mellitus: a meta-analysis. Expert Opinion on PharmacoTherapy 11(9): 1459-1466, 2010

Aspirin for primary prevention of cardiovascular events in patients with diabetes: A meta-analysis. Diabetes Research and Clinical Practice 87(2): 211-218, 2010

Primary prevention of cardiovascular complications in type II diabetes patients using aspirin: a complicated tale. American Journal of Therapeutics 20(3): 275-278, 2013

Low-dose aspirin for primary prevention of cardiovascular events in patients with diabetes: Benefit or risk?. Diabetes and Metabolism 44(3): 217-225, 2017

Low-dose aspirin for primary prevention of cardiovascular events in patients with diabetes: a meta-analysis. American Journal of the Medical Sciences 341(1): 1-9, 2011

Erratum. Aspirin for the Primary Prevention of Cardiovascular Events. A Systematic Review and Meta-Analysis Comparing Patients With and Without Diabetes. Diabetes Care 2009;32:2300-2306. Diabetes Care: -, 2018