+ Site Statistics
+ Search Articles
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ PDF Full Text
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Translate
+ Recently Requested

Prior statin use and the outcomes in patients with first-attack acute pancreatitis: A retrospective cohort study

Prior statin use and the outcomes in patients with first-attack acute pancreatitis: A retrospective cohort study

European Journal of Internal Medicine 26(6): 425-428

We investigated whether prior stain use before admission for a first-attack AP would reduce the severity and mortality rate of a first-attack of AP with a dose-response relationship. We conducted a retrospective cohort study from a tertiary medical center's database in Taiwan. We evaluated the dose-response relationship between statin use and the first-attack of AP by defining the daily dose (DDD). The cumulative DDD (cDDD) was calculated as the sum of the dispensed DDD of any specific statin. The outcome measures in our study included the hospital mortality rate, duration of hospitalization, Ranson's score, computed tomography severity index (CTSI), and C-reactive protein (CRP) level. In our study, we enrolled 31 patients in statin group and 63 matched patients in control group. In the univariate analysis there was no significant difference between them with regard to the outcomes except the CTSI and serum calcium concentration. According to multivariate analysis the serum calcium concentration was significantly higher in the statin group, and the CTSI was lower in the statin group. In subgroup analysis we divided the statin group into two groups according to the cDDDs (<365days and >365days) and the results showed no significance in the demographic data, overall mortality rate, hospitalization days, CRP level, Ranson's score, or CTSI. Our study rejected the hypothesis that statins have beneficial effects on the clinical outcomes of patients with a first-attack of AP. However we demonstrated that statins have a positive effect on the CTSI.

(PDF emailed within 0-6 h: $19.90)

Accession: 058627159

Download citation: RISBibTeXText

PMID: 25997756

DOI: 10.1016/j.ejim.2015.05.002

Related references

Prior statin therapy is associated with milder course and better outcome in acute pancreatitis--a cohort study. Pancreatology 13(3): 196-200, 2014

Epidemiology, aetiology and outcomes of acute pancreatitis: A retrospective cohort study. International Journal of Surgery 23(Pt A): 68-74, 2016

Risk factors and outcomes of infected pancreatic necrosis: Retrospective cohort of 148 patients admitted to the ICU for acute pancreatitis. United European Gastroenterology Journal 6(6): 910-918, 2018

Red cell distribution width and neutrophil to lymphocyte ratio as predictors of outcomes in acute pancreatitis: A retrospective cohort study. International Journal of Surgery 55: 124-127, 2018

Noninvasive Positive-Pressure Ventilation in Acute Respiratory Distress Syndrome in Patients With Acute Pancreatitis: A Retrospective Cohort Study. Pancreas 45(1): 58-63, 2016

Epidural analgesia is infrequently used in patients with acute pancreatitis : a retrospective cohort study. Acta Gastro-Enterologica Belgica 80(3): 381-384, 2018

Iatrogenic Events in ICU Patients Hospitalized for Acute Pancreatitis: A Retrospective Cohort Study. Gastroenterology 152(5): S287-S288, 2017

Early initiation of eicosapentaenoic acid and statin treatment is associated with better clinical outcomes than statin alone in patients with acute coronary syndromes: 1-year outcomes of a randomized controlled study. International Journal of Cardiology 228: 173-179, 2016

Comparison of the prognostic values of inflammation markers in patients with acute pancreatitis: a retrospective cohort study. Bmj Open 7(3): E013206, 2017

Poor outcomes for osteoporotic patients undergoing conversion total hip arthroplasty following prior failed dynamic hip screw fixation: a nationwide retrospective cohort study. Journal of International Medical Research 2019: 300060518823410-300060518823410, 2019

Increased risk of acute pancreatitis and biliary disease observed in patients with type 2 diabetes: a retrospective cohort study. Diabetes Care 32(5): 834-838, 2009

Venous Thromboembolism Is Associated With Adverse Outcomes in Hospitalized Patients With Acute Pancreatitis: A Population-Based Cohort Study. Pancreas 46(9): 1165-1172, 2018

Maternal and newborn outcomes after a prior cesarean birth by planned mode of delivery and history of prior vaginal birth in British Columbia: a retrospective cohort study. Cmaj Open 3(2): E158-E165, 2015

Statin use in patients with cirrhosis: a retrospective cohort study. Digestive Diseases and Sciences 59(8): 1958-1965, 2014

Statin Use and the Risk for Incident Diabetes Mellitus in Patients with Acute Coronary Syndrome after Percutaneous Coronary Intervention: A Population-Based Retrospective Cohort Study in Taiwan. Canadian Journal of Diabetes 40(3): 264-269, 2017