+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Progesterone, estrogen, and androgen receptors in the corpus luteum of the domestic cat, Iberian lynx (Lynx pardinus) and Eurasian lynx (Lynx lynx)

Progesterone, estrogen, and androgen receptors in the corpus luteum of the domestic cat, Iberian lynx (Lynx pardinus) and Eurasian lynx (Lynx lynx)

Theriogenology 86(9): 2107-2118

In contrast to the species studied, the corpus luteum (CL) of Iberian and Eurasian lynx physiologically persists in the ovary for more than 2 years and continues to secrete progesterone. Such persistent CL (perCL) transition into the next cycle and are present in the ovary together with the freshly formed CL (frCL) of a new ovulation. To date, the mechanisms supporting such CL persistence are not known. We analyzed the potential receptivity of feline CL to sex steroids through mRNA measurements of progesterone receptor (PGR), progesterone receptor membrane components (PGRMC) 1 and 2, estrogen receptor (ESR) 1 and ESR2, G protein-coupled estrogen receptor 1 (GPER1), and androgen receptor (AR). All receptors were present in domestic cat CL during pregnancy and the nonpregnant luteal phase, in frCL and perCL of post-mating Iberian lynx and in perCL of pre-mating Eurasian lynx. Mass spectrometry detected the presence of PGRMC1 protein in frCL and perCL of the Iberian lynx. In both domestic cat and lynx CL, PGR, PGRMC1, and ESR1 proteins were localized in luteal cells by immunohistochemistry. The mRNA levels of PGR, PGRMC1, PGRMC2, ESR1, and AR changed significantly throughout the domestic cat luteal phase. This may indicate involvement of these receptors in the processes of formation, maintenance, and regression of feline CL. In Iberian lynx, expression of PGRMC1, PGRCM2, ESR1, GPER1, and AR was significantly higher in perCL compared with frCL, whereas ESR2 was reversed. High mRNA amounts of these receptors in perCL suggest that physiological persistence of lynx CL may be partly regulated by actions of sex steroids through their nuclear and/or membrane receptors.

Please choose payment method:

(PDF emailed within 0-6 h: $19.90)

Accession: 058634422

Download citation: RISBibTeXText

PMID: 27641676

DOI: 10.1016/j.theriogenology.2016.06.026

Related references

Validation of an enzyme immunoassay for the measurement of faecal glucocorticoid metabolites in Eurasian (Lynx lynx) and Iberian lynx (Lynx pardinus). General and Comparative Endocrinology 206: 166-177, 2014

Hormone-induced luteolysis on physiologically persisting corpora lutea in Eurasian and Iberian lynx (Lynx lynx and Lynx pardinus). Theriogenology 82(4): 557-562, 2015

Monitoring testicular activity of male Eurasian (Lynx lynx) and Iberian (Lynx pardinus) lynx by fecal testosterone metabolite measurement. General and Comparative Endocrinology 149(2): 151-158, 2006

Comparative metabolism of gestagens and estrogens in the four lynx species, the Eurasian (Lynx lynx), the Iberian (L. pardinus), the Canada lynx (L. canadensis) and the bobcat (L. rufus). General and Comparative Endocrinology 167(2): 287-296, 2010

On the presumed presence of the Iberian lynx (Lynx pardinus ) during the upper Pleistocene in the territory of Slovenia--O domnevni prisotnosti iberskega risa (Lynx pardinus B) v mlajsem pleistocenu na obmosju Slovenije. Razprave - Slovenska Akademija Znanosti in Umetnosti Razred za Naravoslovne Vede = Dissertationes - Academia Scientiarum et Artium Slovenica, 2005

Predation by the lynx Lynx lynx on wild and domestic ungulates Predation du lynx Lynx lynx sur les ongules sauvages et domestiques. Unknown, 1993

Discussion A promotional strategy for the lynx Lynx lynx in the Palatinate Forest Mit Pinselohr im Dialog eine Komminikationsstrategie fuer den Luchs Lynx lynx im Pfaelzerwald. Annales Scientifiques de la Reserve de la Biosphere des Vosges du Nord, 9: 99-120, 2001

Colonisation of the Jura Mountains by the lynx Lynx lynx and its impact on domestic ungulates Colonisation du massif Jurassien par le lynx Lynx lynx et impact sur les ongules domestiques. Gibier Faune Sauvage, 15: 1161-1169 (Hors serie Tome 3, 1998

Ecology of the lynx Lynx lynx in Bialowieza Primeval Forest Ekologia rysia Lynx lynx w Puszczy Bialowieskiej. Wiadomosci Ekologiczne, 451: 17-41, 1999

Activity recording of a free living lynx Lynx lynx through pursuit of its tracks in the snow Erfassung von Aktivitaten freilebender Luchse Lynx lynx durch das Verfolgen der Fahrten im Schnee. Schriftenreihe fuer Landschaftspflege und Naturschutz, 46: 125-129, 1996

The border crosser with the brush ears The lynx Lynx lynx in the nature reserve Palatine Forest and northern Vosges Der Grenzgaenger mit den Pinselohren Der Luchs Lynx lynx im Biosphaerenreservat Pfaelzerwald-Nordvogesen. Artenschutzreport, 12: 14-20, 2002

Animal for the month of December The lynx Lynx lynx Zival meseca decembra Navadni ris Lynx lynx. Proteus 62(4): 179-182, 1999

Behaviour of Eurasian lynx Lynx lynx in restricted area Mammalia, Carnivora Comportamento della lince eurasiatica Lynx lynx in spazi confinati Mammalia, Carnivora. Atti del Museo di Storia Naturale della Maremma. 31 dicembre; 17: 147-192, 1998

Medetomidine-ketamine-remote anaesthesia of the Eurasian lynx Lynx lynx Linne, 1758 and its effects on anaesthetic depth, respiration, circulation and metabolism Medetomidin-Ketamin-Distanzanaesthesie des Eurasischen Luchses ynx Lynx lynx Linne, 1758 Wirkung auf Anaesthesietiefe, Atem-, Kreislauf- und Stoffwechselfunktionen. Tieraerztliche Praxis Ausgabe K Kleintiere Heimtiere, 306: 454-460, 2002

New data about lynx Lynx lynx occurrence in the province of Belluno NE Italy Nuovi dati sulla lince Lynx lynx L, 1758 in provincia di Belluno. Bollettino del Museo Civico di Storia Naturale di Venezia. 2000( ); 51: 92-95(Suppl.o), 2001