+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Prognostic Impact of Port-Site Metastasis After Diagnostic Laparoscopy for Epithelial Ovarian Cancer



Prognostic Impact of Port-Site Metastasis After Diagnostic Laparoscopy for Epithelial Ovarian Cancer



Annals of Surgical Oncology 23(Suppl 5): 834-840



This study was designed to evaluate the prevalence, morbidity, and prognostic impact of port-site metastasis (PSM) in patients with epithelial ovarian cancer (EOC) undergoing laparoscopy before subsequent primary debulking surgery (PDS). All consecutive patients treated between 2000 and 2014, who had a laparoscopy followed by PDS, were extracted from our prospectively maintained database. All patients with histological examination of port-sites were included in this unicentric exploratory analysis. A total of 250 (25.5 %) of 982 patients with EOC underwent laparoscopy before PDS. Port-site resection was performed in those 214 (85.6 %) patients in whom a complete or almost complete resection with residuals ≤1 cm was achieved. Median interval between laparoscopy and PDS was 25 days. PSM was detected in 100 of 214 patients (46.7 %). Risk factors for PSM were higher tumor stage (odds ratio [OR] 13.5, 95 % confidence interval [CI] 2.9-62.0, p = 0.04), positive lymph node status (OR 3.0, 95 % CI 1.3-6.7, p = 0.009), and ascites >500 mL (OR 3.9, 95 % CI 1.5-10.0, p = 0.005). Wound healing disorders and postoperative morbidity were significantly higher in patients with PSM (Clavien-Dindo Classification grade 3-5: 41.0 vs. 14.9 %, p < 0.001). However, multivariate Cox-regression models did not identify PSM as independent prognostic factor. The prevalence of PSM after laparoscopy in EOC patients is considerably high. PSM had no impact on survival; however, PSM were associated with more postoperative complications and a higher surgical treatment burden. This should be balanced with the expected benefit when laparoscopy is considered for the management of EOC.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 058635000

Download citation: RISBibTeXText

PMID: 27406097

DOI: 10.1245/s10434-016-5415-9


Related references

Unexpected metastatic lobular carcinoma of the breast with intraabdominal spread and subsequent port-site metastasis after diagnostic laparoscopy for exclusion of ovarian cancer. Gynecologic Oncology 95(2): 405-408, 2004

Port-site metastasis after diagnostic laparoscopy for presumably benign ruptured ovarian cyst: disseminated intraperitoneal metastasis of a Krukenberg tumor. Gynecological Surgery 1(4): 267-269, 2004

CT findings in two cases of port-site metastasis after laparoscopy for ovarian cancer. European Journal of Gynaecological Oncology 23(4): 293-294, 2002

Port-site metastasis of mucinous borderline ovarian tumor after laparoscopy. Case Reports in Oncology 7(3): 804-809, 2015

Port site metastasis following diagnostic laparoscopy for a malignant Gastro-intestinal stromal tumour. World Journal of Surgical Oncology 6: 55, 2008

Port site metastasis after diagnostic laparoscopy for upper gastrointestinal tract malignancies: an uncommon entity. Annals of Surgical Oncology 9(7): 632-636, 2002

Port-site metastasis as a primary complication following diagnostic laparoscopy of fallopian tube carcinoma: A case report. Medicine 97(26): E11166, 2018

Port site metastasis after laparoscopy for gynecological cancer: report of two cases. Acta Obstetricia et Gynecologica Scandinavica 79(11): 1021-1023, 2000

Single-port or Classic Laparoscopy Compared With Laparotomy to Assess the Peritoneal Cancer Index in Primary Advanced Epithelial Ovarian Cancer. Journal of Minimally Invasive Gynecology 23(5): 825-832, 2017

Port site resection after laparoscopy in advance ovarian cancer surgery: Time to abandon?. Surgical Oncology 29: 1-6, 2019

Effects of taurolidine and octreotide on port site and liver metastasis after laparoscopy in an animal model of pancreatic cancer. Clinical & Experimental Metastasis 19(2): 169-173, 2002

Management of port-site metastasis after laparoscopic surgery for ovarian cancer. American Journal of Obstetrics & Gynecology 189(1): 16-21, 2003

Diagnostic and prognostic value of tumor markers, scores (clinical and biological) algorithms, in front of an ovarian mass suspected of an epithelial ovarian cancer: Article drafted from the French Guidelines in oncology entitled "Initial management of patients with epithelial ovarian cancer" developed by FRANCOGYN, CNGOF, SFOG, GINECO-ARCAGY under the aegis of CNGOF and endorsed by INCa. Gynecologie, Obstetrique, Fertilite and Senologie 2019, 2019

Prevention of port-site metastasis after laparoscopy. Gynecologie, Obstetrique and Fertilite 30(11): 878-881, 2002

Endometriotic umbilical port site metastasis after laparoscopy. American Journal of Obstetrics and Gynecology 193(5): 1761-1763, 2005