+ Site Statistics
References:
54,258,434
Abstracts:
29,560,870
PMIDs:
28,072,757
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Prognostic Impact of Postoperative Complications in 502 Patients With Surgically Resected Esophageal Squamous Cell Carcinoma: A Retrospective Single-institution Study



Prognostic Impact of Postoperative Complications in 502 Patients With Surgically Resected Esophageal Squamous Cell Carcinoma: A Retrospective Single-institution Study



Annals of Surgery 264(2): 305-311



To investigate the relationship between postoperative complications and long-term survival in patients with surgically resected esophageal squamous cell carcinoma (ESCC). Esophagectomy is the mainstay of curative treatment for ESCC; however, this complex procedure has high risks of postoperative morbidity and mortality. The impact of postoperative complications on long-term survival of such patients remains controversial. This retrospective single institution study included 502 consecutive patients who had undergone resection of ESCC. The Cox proportional hazard model was used to compute the hazard ratio (HR) for mortality. Postoperative complications (≥Clavien-Dindo classification grade 2) occurred in 217 patients (43%). Overall, postoperative complications did not affect long-term clinical outcomes of these patients. However, patients with pulmonary complications had worse overall survival than those without pulmonary complications [log rank P = 0.0002; univariate HR = 1.51, 95% confidence interval (CI) 1.20-1.88, P = 0.0006; multivariate HR = 1.60, 95% CI 1.05-2.38, P = 0.029]. The effect of pulmonary complications was not significantly modified by clinical or pathological features (P for all assessed interactions >0.05). In addition, postoperative chylothorax was also associated with poor overall survival (log rank P = 0.0021), whereas surgical site infection, recurrent nerve paralysis, cardiovascular complication, and anastomotic leakage were not. Postoperative pulmonary complications may be an independent predictor of poorer long-term survival in patients undergoing resection of ESCCs.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 058635001

Download citation: RISBibTeXText

PMID: 26670288

DOI: 10.1097/sla.0000000000001510


Related references

Is the prognostic impact of tumor location in patients with surgically resected esophageal squamous cell carcinoma affected by surgical approach?. European Surgical Research. Europaische Chirurgische Forschung. Recherches Chirurgicales Europeennes 51(1-2): 91-98, 2014

Prognostic Impact of Postoperative Complications on Overall Survival in 287 Patients With Oral Cancer: A Retrospective Single-Institution Study. Journal of Oral and Maxillofacial Surgery 2019, 2019

Prognostic significance of venous invasion and maximum standardized uptake value of 18 F-FDG PET/CT in surgically resected T1N0 esophageal squamous cell carcinoma. European Journal of Surgical Oncology 43(2): 471-477, 2016

Prognostic Significance of Postoperative Complications After Curative Resection for Patients With Esophageal Squamous Cell Carcinoma. Annals of Surgery 265(3): 527-533, 2017

Prognostic Significance of Postoperative Complications After Curative Resection for Patients With Esophageal Squamous Cell Carcinoma. Annals of Surgery (): -, 2016

Clinicopathological significance of LAT1 and ASCT2 in patients with surgically resected esophageal squamous cell carcinoma. Journal of Surgical Oncology 113(4): 381-389, 2016

Overexpression of cystatin SN positively affects survival of patients with surgically resected esophageal squamous cell carcinoma. Bmc Surgery 13: 15, 2013

Deregulated p21(WAF1) overexpression impacts survival of surgically resected esophageal squamous cell carcinoma patients. Annals of Thoracic Surgery 80(3): 1007-1016, 2005

Influence of Neoadjuvant Therapy on Poor Long-Term Outcomes of Postoperative Complications in Patients with Esophageal Squamous Cell Carcinoma: A Retrospective Cohort Study. Annals of Surgical Oncology 2019, 2019

Reduction of p12DOC-1 expression is a negative prognostic indicator in patients with surgically resected oral squamous cell carcinoma. Clinical Cancer Research 7(9): 2776-2782, 2001

Systemic immune-inflammation index (Sii) is useful to predict survival outcomes in patients with surgically resected esophageal squamous cell carcinoma. Journal of Cancer 10(14): 3188-3196, 2019

Concurrent three-dimensional conformal radiotherapy and chemotherapy for postoperative recurrence of mediastinal lymph node metastases in patients with esophageal squamous cell carcinoma: a phase 2 single-institution study. Radiation Oncology 9: 28, 2014

Significance of involvement by squamous cell carcinoma of the ducts of esophageal submucosal glands: Analysis of 201 surgically resected superficial squamous cell carcinomas. Cancer 89(2): 248-254, July 15, 2000

Expression and prognostic value of MG7-Ag in patients with surgically resectable esophageal squamous cell carcinoma. Annals of Surgical Oncology 14(9): 2621-2627, 2007

Prognostic impact of cigarette smoking on the survival of patients with established esophageal squamous cell carcinoma receiving radiotherapy: A retrospective study from southern China. Experimental and Therapeutic Medicine 17(5): 3671-3681, 2019