+ Site Statistics
+ Search Articles
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ PDF Full Text
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Translate
+ Recently Requested

Prognostic significance of initial recurrence site in hematogenous recurrence of esophageal squamous cell carcinoma

Prognostic significance of initial recurrence site in hematogenous recurrence of esophageal squamous cell carcinoma

Hepato-Gastroenterology 61(136): 2241-2246

Hematogenous recurrences of esophageal squamous cell carcinoma (ESCC) have dismal prognoses, but prognostic heterogeneity exists in this disease. The objectives of this study were to clarify the prognosis in this disease with regard to the initial recurrence site and to define the prognostic factors. We retrospectively reviewed the cases of 67 consecutive patients with hematogenous recurrence in major organs after esophagectomy for ESCC of the thoracic esophagus and the esophagogastric junction. We analyzed clinicopathological characteristics, survival probability, and potential prognostic factors. Lung, liver, bone, and multiple-organ metastases occurred in 24, 19, 14, and 10 patients, respectively. Twenty-seven patients simultaneously had locoregional recurrence (combined recurrence). Among all 67 patients, the median disease-free interval (DFI) was 9.7 months, and the median survival time after the initial recurrence was 4.9 months. The patients with initial lung metastasis had most favorable prognosis with the median survival time of 9.8 months. A multivariate analysis identified that initial recurrence site, DFI, combined recurrence, and anti-cancer therapy were independent prognostic factors. The initial recurrence site contributes to the prognostic heterogeneity of patients with hematogenous recurrence of ESCC. The prognostic factors identified in this study are useful to optimize the management of these patients.

(PDF emailed within 1 workday: $29.90)

Accession: 058637155

Download citation: RISBibTeXText

PMID: 25699360

Related references

Prognostic factors for post-recurrence survival in esophageal squamous cell carcinoma patients with recurrence after resection. Journal of Gastrointestinal Surgery 15(4): 558-565, 2011

Carbohydrate antigens as a risk factor for hematogenous recurrence of esophageal squamous cell carcinoma patients. Oncology Reports 8(5): 981-985, 2001

High expression of glucose transporter 1 on primary lesions of esophageal squamous cell carcinoma is associated with hematogenous recurrence. Annals of Surgical Oncology 21(5): 1756-1762, 2014

TGFBI Expression in Cancer Stromal Cells is Associated with Poor Prognosis and Hematogenous Recurrence in Esophageal Squamous Cell Carcinoma. Annals of Surgical Oncology 23(1): 282-289, 2016

Treatment Outcomes and Prognostic Factors After Recurrence of Esophageal Squamous Cell carcinoma. World Journal of Surgery: -, 2017

Prognostic factors in patients with recurrence after complete resection of esophageal squamous cell carcinoma. Journal of Thoracic Disease 6(7): 949-957, 2014

Cohypermethylation of p14 in combination with CADM1 or DCC as a recurrence-related prognostic indicator in stage I esophageal squamous cell carcinoma. Cancer 119(9): 1752-1760, 2013

Preoperative hepatic CT perfusion as an early predictor for the recurrence of esophageal squamous cell carcinoma: initial clinical results. Oncology Reports 31(3): 1083-1088, 2014

Prognostic Factors for Post-Recurrence Survival in Patients with Thoracic Esophageal Squamous Cell Carcinoma after Curative Resection. Digestive Surgery 33(2): 136-145, 2016

A retrospective evaluation of radiotherapy for the treatment of local esophageal squamous cell carcinoma recurrence after initial complete surgical resection. Journal of Investigative Medicine 61(1): 34-39, 2014

Factors predictive of tumor recurrence and survival after initial complete response of esophageal squamous cell carcinoma to definitive chemoradiotherapy. International Journal of Radiation Oncology, Biology, Physics 76(1): 123-129, 2010

Elevation of circulating big endothelin-1: an independent prognostic factor for tumor recurrence and survival in patients with esophageal squamous cell carcinoma. Bmc Cancer 8(): 334-334, 2008

The total number of resected lymph node is not a prognostic factor for recurrence in esophageal squamous cell carcinoma patients undergone transthoracic esophagectomy. Journal of Surgical Oncology 103(5): 416-420, 2011

Submucosal tumor appearance is a useful endoscopic predictor of early primary-site recurrence after definitive chemoradiotherapy for esophageal squamous cell carcinoma. Diseases of the Esophagus 24(4): 274-278, 2011

Squamous cell carcinoma-antigen messenger RNA level in peripheral blood predicts recurrence after resection in patients with esophageal squamous cell carcinoma. Surgery 139(5): 678-685, 2006