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Prognostic significance of osteopontin in patients with non-small cell lung cancer: results from a meta-analysis



Prognostic significance of osteopontin in patients with non-small cell lung cancer: results from a meta-analysis



International Journal of Clinical and Experimental Medicine 8(8): 12765-12773



Non-small cell lung cancer (NSCLC) is one of the most common malignancies with a high mortality level. Recently, a variety of studies explored the role of osteopontin (OPN) expression in the prognosis of NSCLC, but the results were controversial. We performed a meta-analysis of eligible studies to evaluate the prognostic significance of OPN expression in NSCLC patients. In order to assess the association between OPN and OS and DFS/PFS, hazard ratio (HR) with 95% confidence interval (CI) was calculated. A total of ten studies comprising 1420 patients were included in the meta-analysis. The summary results indicated that high OPN expression was a poor predictor for OS (HR = 2.19, 95% CI: 1.6-2.98), and DFS/PFS (HR = 2, 95% CI: 1.66-2.41). Subgroup analysis revealed that high OPN expression was a negative prognostic marker for OS and DFS/PFS regardless of ethnicity background, treatment and OPN detection method. Our results showed that increased OPN expression significantly correlated with poor OS and DPS/PFS in NSCLC patients.

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Accession: 058637241

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PMID: 26550190


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