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Prognostic significance of overexpressed p16(INK4A) in esophageal squamous cell carcinoma: a meta-analysis



Prognostic significance of overexpressed p16(INK4A) in esophageal squamous cell carcinoma: a meta-analysis



Biomarkers in Medicine 10(5): 537-546



The prognostic value of p16(INK4A) in esophageal squamous cell carcinoma (ESCC) has been evaluated for several years although the results remain controversial. Various databases were systematically searched to identify studies published on the p16(INK4A) survival rate of ESCC patients. The pooled risk ratios and odds ratios with their corresponding 95% CIs were used to estimate the effect sizes. A total of 16 studies comprising 1314 patients were included. p16(INK4A) overexpression was significantly associated with improved 5-year overall survival, disease-free survival, early tumor TNM stages, better tumor histological grade, no lymph node metastasis and more shallow tumor invasive depth (p < 0.05). p16(INK4A) expression could be a useful biomarker to predict better prognosis for ESCC patients.

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Accession: 058637243

Download citation: RISBibTeXText

PMID: 27071776

DOI: 10.2217/bmm-2015-0057


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