+ Site Statistics
+ Search Articles
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ PDF Full Text
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Translate
+ Recently Requested

Prognostic significance of pretreatment VEGF, survivin, and Smac/DIABLO serum levels in patients with serous ovarian carcinoma

Prognostic significance of pretreatment VEGF, survivin, and Smac/DIABLO serum levels in patients with serous ovarian carcinoma

Tumour Biology 36(6): 4157-4165

The second mitochondria-derived activator of caspase (Smac/DIABLO), vascular endothelial growth factor (VEGF), and survivin are known to play a significant role in the growth and development of numerous tumors. Serum concentrations of VEGF, survivin, and Smac/DIABLO were analyzed in 92 patients with serous ovarian cancer and 94 healthy controls. Values were correlated with clinicopathological characteristics and outcomes. The median pretreatment serum VEGF and survivin levels in patients with serous ovarian carcinoma were significantly higher, while Smac/DIABLO levels were significantly lower than that in healthy controls. Receiver operating characteristic (ROC) curve analysis showed that the best cutoff point for VEGF was determined to be 345 pg/ml; with 83 % sensitivity and 65 % specificity. For survivin, the cutoff point was 110 pg/ml and for Smac/DIABLO was 75 pg/ml, with 82 and 62 % sensitivity and 43 and 87 % specificity, respectively. In the patients group, higher VEGF and survivin levels and lower Smac/DIABLO levels in sera were significantly associated with poorer overall survival (OS) and disease-free survival (DFS). Preoperative measurement of serum VEGF, survivin, and Smac/DIABLO may be of help in early detection of serous ovarian cancer and may provide important information about the patient's outcome and prognosis.

(PDF emailed within 0-6 h: $19.90)

Accession: 058637287

Download citation: RISBibTeXText

PMID: 25577253

DOI: 10.1007/s13277-015-3050-x

Related references

Survivin interacts with Smac/DIABLO in ovarian carcinoma cells but is redundant in Smac-mediated apoptosis. Experimental Cell Research 302(1): 69-82, 2004

Prognostic significance of Smac/DIABLO expression in renal cell carcinoma. Journal of Clinical Oncology 23(16_suppl): 4657-4657, 2016

Downregulation of Smac/DIABLO expression in renal cell carcinoma and its prognostic significance. Journal of Clinical Oncology 23(3): 448-454, 2004

Clinicopathologic and prognostic significance of serum levels of cytokines in patients with advanced serous ovarian cancer prior to surgery. Zhonghua Bing Li Xue Za Zhi 39(10): 666-670, 2011

MAD2 Expression in Ovarian Carcinoma: Different Expression Patterns and Levels among Various Types of Ovarian Carcinoma and Its Prognostic Significance in High-Grade Serous Carcinoma. Korean Journal of Pathology 47(5): 418-425, 2013

Pretreatment serum levels of bFGF and VEGF and its clinical significance in endometrial carcinoma. Gynecologic Oncology 128(3): 454-460, 2013

Direct interaction between survivin and Smac/DIABLO is essential for the anti-apoptotic activity of survivin during taxol-induced apoptosis. Journal of Biological Chemistry 278(25): 23130-23140, 2003

Prognostic significance of pretreatment serum levels of squamous cell carcinoma antigen and CA 125 in cervical carcinoma. European Journal of Cancer 28a(10): 1695-1702, 1992

Prognostic significance of smac/DIABLO in endometrioid endometrial cancer. Folia Histochemica et Cytobiologica 48(4): 678-681, 2011

Low circulating serum levels of second mitochondria-derived activator of caspase (Smac/DIABLO) in patients with bladder cancer. International Journal of Oncology 40(4): 1246-1250, 2012

Histologic grading of advanced serous ovarian carcinoma has no prognostic significance in patients treated with cisplatinum. International Journal of Gynecology & Obstetrics (ABSTR SUPPL): 517, 1991

Smac/DIABLO expression in human gastrointestinal carcinoma: Association with clinicopathological parameters and survivin expression. Oncology Letters 8(6): 2581-2586, 2014

Expression and significance of Survivin and Smac in ovarian mucinous tumors. Zhonghua Bing Li Xue Za Zhi 39(6): 387-390, 2011

Prognostic significance of second mitochondria-derived activator of caspase (Smac/DIABLO) expression in bladder cancer and target for therapy. International Journal of Oncology 37(2): 503-508, 2010

Minocycline inhibits caspase activation and reactivation, increases the ratio of XIAP to smac/DIABLO, and reduces the mitochondrial leakage of cytochrome C and smac/DIABLO. Journal of the American College of Cardiology 43(5): 865-874, 2004