+ Site Statistics
References:
54,258,434
Abstracts:
29,560,870
PMIDs:
28,072,757
+ Search Articles
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ PDF Full Text
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Translate
+ Recently Requested

Prognostic significance of survivin in resected gallbladder cancer



Prognostic significance of survivin in resected gallbladder cancer



Journal of Surgical Research 194(1): 57-62



Survivin, a novel inhibitor of apoptosis, plays a role in oncogenesis and has been correlated with poor prognosis. We investigated its expression in gallbladder tissues of control, cholelithiasis, and gallbladder cancer (GBC). Survivin expression was correlated with different clinicopathologic parameters including prognosis in patients with GBC. Gallbladder tissue samples were collected from GBC (n = 39), cholelithiasis (n = 30), and control (n = 25). Expression of survivin messenger RNA (mRNA) was evaluated by real time polymerase chain reaction. Protein quantification was done by enzyme-linked immunosorbent assay. Significantly higher expression of survivin mRNA was observed in GBC (2.9-fold) and cholelithiasis (1.85-fold) as compared with control (P < 0.0001). In GBC, increased survivin expression (mRNA and protein) was significantly associated with higher tumor stage (stage III versus stage II) (P < 0.0001) and poor tumor differentiation (poor and moderate versus well) (P < 0.0001). No significant correlation was observed with any of the other clinicopathologic factors studied. Increased expression of survivin was associated with shorter survival (median survival 11.5 mo versus 18 mo). Differential expression of survivin in GBC suggests its possible role in gallbladder carcinogenesis. Its overexpression is associated with poor prognosis. Assessment of survivin might be used to stratify GBC patients for optimal treatment modalities, including targeted therapy.

(PDF emailed within 0-6 h: $19.90)

Accession: 058637336

Download citation: RISBibTeXText

PMID: 25472573

DOI: 10.1016/j.jss.2014.07.054


Related references

Prognostic significance of K-ras codon 12 mutation in patients with resected gallbladder cancer. Digestive Surgery 30(3): 233-239, 2014

Prognostic significance of pre-operative inflammatory markers in resected gallbladder cancer: a systematic review. Anz Journal of Surgery: -, 2017

Lack of prognostic significance of survivin, survivin-deltaEx3, survivin-2B, galectin-3, bag-1, bax-alpha and MRP-1 mRNAs in breast cancer. Cancer Letters 201(2): 225-236, 2003

The prognostic significance of survivin expression in gallbladder carcinoma. Apmis 124(8): 633-638, 2016

Prognostic significance of nuclear survivin expression in resected adenoid cystic carcinoma of the head and neck. Head & Neck Oncology 2(): 30-30, 2011

Expression of survivin mRNA in gallbladder cancer: a diagnostic and prognostic marker?. Tumour Biology 35(9): 9241-9246, 2014

Expression and clinicopathological significance of antiapoptotis protein survivin in gallbladder cancer. Indian Journal of Pathology & Microbiology 59(2): 143-147, 2016

Prognostic significance of promoter DNA hypermethylation of the cysteine dioxygenase 1 (CDO1) gene in primary gallbladder cancer and gallbladder disease. Plos One 12(11): E0188178-E0188178, 2017

Expressions of survivin and the splice variants survivin-2B and survivin-DeltaEx3 in bladder cancer and their clinical significance. Ai Zheng 28(11): 1209-1213, 2011

The prognostic significance of COX-2 and survivin expression in ovarian cancer. Pathology, Research and Practice 204(4): 241-249, 2008

Prognostic significance of survivin in breast cancer: meta-analysis. Breast Journal 20(5): 514-524, 2015

Clinicopathologic Significance of Survivin Expression in Relation to CD133 Expression in Surgically Resected Stage II or III Colorectal Cancer. Journal of Pathology and Translational Medicine 51(1): 17-23, 2016

Prognostic significance of Survivin and CD44v6 in laryngeal cancer surgical margins. Journal of Cancer Research and Clinical Oncology 134(10): 1051-1058, 2008

Significance of survivin as a prognostic factor and a therapeutic target in endometrial cancer. Gynecologic Oncology 141(3): 564-569, 2016

Prognostic and clinicopathological significance of survivin in colorectal cancer: a meta-analysis. Plos One 8(6): E65338-E65338, 2015