+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Proteomic profiling of human plasma for cancer biomarker discovery



Proteomic profiling of human plasma for cancer biomarker discovery



Proteomics 17(6)



Over the past decades, substantial advances have been made in both the early diagnosis and accurate prognosis of many cancers because of the impressive development of novel proteomic strategies. However, it remains difficult to standardize proteomic approaches. In addition, the heterogeneity of proteins in distinct tissues results in incomplete population of the whole proteome, which inevitably limits its clinical practice. As one of the most complex proteomes in the human body, the plasma proteome contains secreted proteins originating from multiple organs and tissues, making it a favorable matrix for comprehensive biomarker discovery. Here, we will discuss the roles of plasma proteome profiling in cancer biomarker discovery and validation, and highlight both the inherent advantages and disadvantages. Although several hurdles lay ahead, further advances in this technology will greatly increase our understanding of cancer biology, reveal new biomarkers and biomarker panels, and open a new avenue for more efficient early diagnosis and surveillance of cancer, leading toward personalized medicine.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 058653489

Download citation: RISBibTeXText

PMID: 27550791

DOI: 10.1002/pmic.201600240


Related references

Time course proteomic profiling of human myocardial infarction plasma samples: an approach to new biomarker discovery. Clinica Chimica Acta; International Journal of Clinical Chemistry 412(11-12): 1086-1093, 2012

Differential gel-based proteomic approach for cancer biomarker discovery using human plasma. Methods in Molecular Biology 854: 223-237, 2012

Proteomic global profiling for cancer biomarker discovery. Methods in Molecular Biology 492: 309-320, 2009

Proteomic Profiling for Colorectal Cancer Biomarker Discovery. Methods in Molecular Biology 1765: 241-269, 2018

Proteomic profiling of pancreatic cancer for biomarker discovery. Molecular and Cellular Proteomics 4(4): 523-533, 2005

Integrated proteomic analysis of human cancer cells and plasma from tumor bearing mice for ovarian cancer biomarker discovery. Plos One 4(11): E7916, 2010

Biomarker discovery: a proteomic approach for brain cancer profiling. Cancer Science 98(2): 201-213, 2007

Discovery of a diagnostic biomarker for colon cancer through proteomic profiling of small extracellular vesicles. Bmc Cancer 18(1): 1058, 2018

Fast quantitative urinary proteomic profiling workflow for biomarker discovery in kidney cancer. Clinical Proteomics 15: 42-42, 2019

Capillary electrophoresis coupled to mass spectrometry for proteomic profiling of human urine and biomarker discovery. Methods in Molecular Biology 564: 105-121, 2009

An application of the 2-nitrobenzenesulfenyl method to proteomic profiling of human colorectal carcinoma: A novel approach for biomarker discovery. Proteomics. Clinical Applications 2(6): 925-935, 2008

Proteomic approaches for cancer biomarker discovery in plasma. Expert Review of Proteomics 4(5): 589-590, 2007

Utilizing human blood plasma for proteomic biomarker discovery. Journal of Proteome Research 4(4): 1073-1085, 2005

Cancer biomarker discovery in plasma using a tissue-targeted proteomic approach. Cancer Epidemiology, Biomarkers & Prevention 16(10): 1915-1917, 2007

Proteomic Biomarker Discovery in 1000 Human Plasma Samples with Mass Spectrometry. Journal of Proteome Research 15(2): 389-399, 2016