+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Psychosocial factors in adherence to antiretroviral therapy among HIV-positive people who use drugs



Psychosocial factors in adherence to antiretroviral therapy among HIV-positive people who use drugs



Health Psychology 35(3): 290-297



Suboptimal adherence to antiretroviral therapy (ART) among HIV-infected people who use illicit drugs (PWUD) remains a significant concern, and there is a lack of effective adherence interventions for this population. Therefore, we sought to identify psychosocial determinants of optimal adherence, including adherence self-efficacy and outcome expectancies, with the aim of informing interventions designed to improve adherence among PWUD. From December 2005 to November 2013, we collected data from the AIDS Care Cohort to evaluate Exposure to Survival Services (ACCESS), a prospective cohort of PWUD in Vancouver, Canada. We used multivariable generalized estimating equations (GEE) analysis to identify longitudinal factors independently associated with 95% or greater adherence to ART. Among 667 participants, including 220 (33%) women, 391 (59%) had 95% or greater ART adherence at baseline. In multivariable GEE analysis, adherence self-efficacy, adjusted odds ratio (AOR) = 1.16, 95% confidence interval (CI) [1.11, 1.21] per 10-point increase, was independently and positively associated with adherence, while negative outcome expectancy, AOR = 0.95, 95% CI [0.93, 0.98], was negatively associated. In light of the ongoing challenges associated with ART adherence among HIV-positive PWUD, and our findings of associations between adherence, self-efficacy, and outcomes expectancies, tailored intervention strategies based on constructs of social learning theory should be implemented and evaluated to improve adherence among HIV-infected PWUD.

Please choose payment method:






(PDF emailed within 1 workday: $29.90)

Accession: 058660277

Download citation: RISBibTeXText

PMID: 26690643


Related references

Individual, social, and structural factors affecting antiretroviral therapy adherence among HIV-positive people who inject drugs in Kazakhstan. International Journal on Drug Policy 62: 43-50, 2018

Perceived effectiveness of antiretroviral therapy, self-rated health and treatment adherence among HIV-positive people who inject drugs in Estonia. International Journal of Std and Aids 29(1): 13-22, 2018

Factors associated with initiation of antiretroviral therapy among HIV-positive people who use injection drugs in a Canadian setting. Aids 30(6): 925-932, 2016

Factors influencing antiretroviral therapy adherence among HIV-infected people on antiretroviral therapy in Ili Kazakh Autonomous Prefecture. Zhonghua Yu Fang Yi Xue Za Zhi 51(2): 160-164, 2017

Adherence to antiretroviral therapy: factors independently associated with reported difficulty taking antiretroviral therapy in a national sample of HIV-positive Australians. HIV Medicine 12(9): 562-569, 2011

Psychosocial factors associated with adherence to antiretroviral medications in a sample of HIV-positive African American drug users. Aids Care 16(4): 458-470, 2004

Associations between alcohol use, other psychosocial factors, structural factors and antiretroviral therapy (ART) adherence among South African ART recipients. Aids and Behavior 18(3): 519-524, 2014

Factors associated with antiretroviral medication adherence among HIV-positive adults accessing highly active antiretroviral therapy (HAART) in British Columbia, Canada. Journal of the International Association of Physicians in Aids Care 11(2): 134-141, 2014

Engagement in Maximally-Assisted Therapy and Adherence to Antiretroviral Therapy Among a Cohort of Indigenous People Who Use Illicit Drugs. Aids and Behavior 23(5): 1258-1266, 2019

High-intensity cannabis use and adherence to antiretroviral therapy among people who use illicit drugs in a Canadian setting. Aids and Behavior 19(1): 120-127, 2015

Factors associated with adherence amongst 5,295 people on antiretroviral therapy as part of an international trial. 2013

Factors affecting adherence to antiretroviral therapy in people living with HIV/AIDS. Journal of the Association of Nurses in Aids Care 14(4): 37-45, 2003

Analysis of the social and psychosocial factors associated with adherence to antiretroviral therapy in adolescents with perinatal HIV-1 infection in Panama from a gender perspective. Aids Care 28(Suppl. 2): 66-72, 2016

Psychosocial factors affecting medication adherence among HIV-1 infected adults receiving combination antiretroviral therapy (cART) in Botswana. Aids Research and Human Retroviruses 26(6): 685-691, 2010

A Longitudinal Analysis of Daily Pill Burden and Likelihood of Optimal Adherence to Antiretroviral Therapy Among People Living With HIV Who Use Drugs. Journal of Addiction Medicine 12(4): 308-314, 2018