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Pyroacm Resin: An Acetamidomethyl Derived Resin for Solid Phase Synthesis of Peptides through Side Chain Anchoring of C-Terminal Cysteine Residues

Juvekar, V.; Gong, Y.Dae.

Organic Letters 18(4): 836-839

2016

ISSN/ISBN: 1523-7060
PMID: 26845647
DOI: 10.1021/acs.orglett.6b00115
Accession: 058667185
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The design, synthesis and utilization of an efficient acetamidomethyl derived resin for the peptide synthesis is presented using established Fmoc and Boc protocols via side chain anchoring. Cleavage of the target peptide from the resin is performed using carboxymethylsulfenyl chloride under mild conditions which gave in situ thiol-sulfenyl protection of the cysteine residues. The utility of the resin is successfully demonstrated through applications to the syntheses of model peptides and natural products Riparin 1.1 and Riparin 1.2.

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Related References

Juvekar, V.; Gong, Y.D. 2016: Pyroacm Resin: An Acetamidomethyl Derived Resin for Solid Phase Synthesis of Peptides through Side Chain Anchoring of C-Terminal Cysteine Residues Organic Letters 18(4): 836-839
García-Ramos, Y.és.; Giraud, M.; Tulla-Puche, J.; Albericio, F. 2009: Optimized Fmoc solid-phase synthesis of Thymosin alpha1 by side-chain anchoring onto a PEG resin Biopolymers 92(6): 565-572
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