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RIFM fragrance ingredient safety assessment, α-Ionone, CAS Registry Number 127-41-3


RIFM fragrance ingredient safety assessment, α-Ionone, CAS Registry Number 127-41-3



Food and Chemical Toxicology: An International Journal Published for the British Industrial Biological Research Association 97s: S1-S10



ISSN/ISBN: 0278-6915

PMID: 26702988

DOI: 10.1016/j.fct.2015.12.010

The use of this material under current use conditions is supported by the existing information. This material was evaluated for genotoxicity, repeated dose toxicity, developmental toxicity, reproductive toxicity, local respiratory toxicity, phototoxicity, skin sensitization potential, as well as, environmental safety. Repeated dose toxicity was determined to have the most conservative systemic exposure derived NO[A]EL of 10 mg/kg/day. A dietary 90-day subchronic toxicity study conducted in rats resulted in a MOE of 182 while assuming 100% absorption from skin contact and inhalation. A MOE of >100 is deemed acceptable.

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Accession: 058681068

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