+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Randomized Trial of a Lifestyle Program in Obese Infertile Women

Randomized Trial of a Lifestyle Program in Obese Infertile Women

New England Journal of Medicine 374(20): 1942-1953

Small lifestyle-intervention studies suggest that modest weight loss increases the chance of conception and may improve perinatal outcomes, but large randomized, controlled trials are lacking. We randomly assigned infertile women with a body-mass index (the weight in kilograms divided by the square of the height in meters) of 29 or higher to a 6-month lifestyle intervention preceding treatment for infertility or to prompt treatment for infertility. The primary outcome was the vaginal birth of a healthy singleton at term within 24 months after randomization. We assigned women who did not conceive naturally to one of two treatment strategies: 290 women were assigned to a 6-month lifestyle-intervention program preceding 18 months of infertility treatment (intervention group) and 287 were assigned to prompt infertility treatment for 24 months (control group). A total of 3 women withdrew consent, so 289 women in the intervention group and 285 women in the control group were included in the analysis. The discontinuation rate in the intervention group was 21.8%. In intention-to-treat analyses, the mean weight loss was 4.4 kg in the intervention group and 1.1 kg in the control group (P<0.001). The primary outcome occurred in 27.1% of the women in the intervention group and 35.2% of those in the control group (rate ratio in the intervention group, 0.77; 95% confidence interval, 0.60 to 0.99). In obese infertile women, a lifestyle intervention preceding infertility treatment, as compared with prompt infertility treatment, did not result in higher rates of a vaginal birth of a healthy singleton at term within 24 months after randomization. (Funded by the Netherlands Organization for Health Research and Development; Netherlands Trial Register number, NTR1530.).

Please choose payment method:

(PDF emailed within 0-6 h: $19.90)

Accession: 058689113

Download citation: RISBibTeXText

PMID: 27192672

DOI: 10.1056/NEJMoa1505297

Related references

Randomized trial of a lifestyle program in obese infertile women. Nederlands Tijdschrift Voor Geneeskunde 160: D916, 2018

Effect of a lifestyle intervention in obese infertile women on cardiometabolic health and quality of life: A randomized controlled trial. Plos One 13(1): E0190662, 2018

Effects of a preconception lifestyle intervention in obese infertile women on diet and physical activity; A secondary analysis of a randomized controlled trial. Plos One 13(11): E0206888, 2018

An Interdisciplinary Lifestyle Intervention Improves Clinically Relevant Fertility Outcomes in Obese Infertile Women Preliminary Results of a Randomized Controlled Trial. Canadian Journal of Diabetes 39(6): 532-533, 2015

The Obesity-Fertility Protocol: a randomized controlled trial assessing clinical outcomes and costs of a transferable interdisciplinary lifestyle intervention, before and during pregnancy, in obese infertile women. Bmc Obesity 2: 47, 2015

The LiP (Lifestyle in Pregnancy) study: a randomized controlled trial of lifestyle intervention in 360 obese pregnant women. Diabetes Care 34(12): 2502-2507, 2012

Metabolic effects of lifestyle intervention in obese pregnant women. Results from the randomized controlled trial 'Lifestyle in Pregnancy' (LiP). Diabetic Medicine 31(11): 1323-1330, 2015

The LIFESTYLE study: costs and effects of a structured lifestyle program in overweight and obese subfertile women to reduce the need for fertility treatment and improve reproductive outcome. A randomised controlled trial. Bmc Women's Health 10: 22, 2010

Weight reduction intervention for obese infertile women prior to IVF: a randomized controlled trial. Human Reproduction 32(8): 1621-1630, 2018

Lifestyle intervention in obese Arab women: a randomized controlled trial. Archives of Internal Medicine 170(11): 970-976, 2010

Comparison of Methods for Delivering a Lifestyle Modification Program for Obese Patients: A Randomized Trial. Yearbook of Anesthesiology and Pain Management 2010: 32-33, 2010

Comparison of methods for delivering a lifestyle modification program for obese patients: a randomized trial. Annals of Internal Medicine 150(4): 255-262, 2009

Feasibility and effectiveness of a lifestyle intervention program in obese endometrial cancer patients: a randomized trial. Gynecologic Oncology 109(1): 19-26, 2008

Dietary and lifestyle advice for pregnant women who are overweight or obese: the LIMIT randomized trial. Annals of Nutrition and Metabolism 64(3-4): 197-202, 2015

Effects of lifestyle activity vs structured aerobic exercise in obese women: a randomized trial. JAMA 281(4): 335-340, 1999