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Regiospecific Synthesis of Benzoxepines through Pd-Catalyzed Carbene Migratory Insertion and C-C Bond Cleavage

Regiospecific Synthesis of Benzoxepines through Pd-Catalyzed Carbene Migratory Insertion and C-C Bond Cleavage

Journal of Organic Chemistry 81(5): 2128-2134

A new method for the synthesis of benzoxepines via migratory insertion into a Pd carbene followed by C-C bond cleavage was developed. Various benzoxepines were constructed by the regioselective ring expansion concomitant with the introduction of an aryl group at their 5-position.

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Accession: 058722863

Download citation: RISBibTeXText

PMID: 26841938

DOI: 10.1021/acs.joc.5b02413

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