+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Regulation of group 2 innate lymphoid cells

Regulation of group 2 innate lymphoid cells

Cytokine 87: 1-8

Group 2 innate lymphoid cells (ILC2) exert critical roles in type 2 immune responses, epithelial repair at mucosal tissues and metabolic homeostasis. ILC2 rapidly provide large amounts of type 2 signature cytokines, thereby driving type 2 immune responses such as the defense against helminths. However, if deregulated, ILC2 facilitate tissue fibrosis and trigger unwanted type 2 immunopathologies such as allergies, asthma and atopic dermatitis. Therefore, ILC2 need to be tightly regulated and we are just beginning to understand which mediators activate or inhibit this rare but important cell population. In this review, we summarize current knowledge about positive and negative regulation of ILC2 and discuss its immunological consequences.

Please choose payment method:

(PDF emailed within 0-6 h: $19.90)

Accession: 058724994

Download citation: RISBibTeXText

PMID: 27255596

DOI: 10.1016/j.cyto.2016.01.018

Related references

Induction of human regulatory innate lymphoid cells from group 2 innate lymphoid cells by retinoic acid. Journal of Allergy and Clinical Immunology 2019, 2019

Group 2 innate lymphoid cells in the regulation of immune responses. Advances in Immunology 125: 111-154, 2015

Cutaneous immunosurveillance and regulation of inflammation by group 2 innate lymphoid cells. Nature Immunology 14(6): 564-573, 2013

Regulation of metabolic health and adipose tissue function by group 2 innate lymphoid cells. European Journal of Immunology 46(6): 1315-1325, 2017

Neuropilin-1 Is Expressed on Lymphoid Tissue Residing LTi-like Group 3 Innate Lymphoid Cells and Associated with Ectopic Lymphoid Aggregates. Cell Reports 18(7): 1761-1773, 2017

Vagal Regulation of Group 3 Innate Lymphoid Cells and the Immunoresolvent PCTR1 Controls Infection Resolution. Immunity 46(1): 92-105, 2017

Host resistance to endotoxic shock requires the neuroendocrine regulation of group 1 innate lymphoid cells. Journal of Experimental Medicine 214(12): 3531-3541, 2017

Cytokine and Lipid Mediator Regulation of Group 2 Innate Lymphoid Cells (ILC2s) in Human Allergic Airway Disease. Journal of Cytokine Biology 2(2), 2017

Group 3 innate lymphoid cells inhibit T-cell-mediated intestinal inflammation through aryl hydrocarbon receptor signaling and regulation of microflora. Immunity 39(2): 386-399, 2013

The messenger between worlds: the regulation of innate and adaptive type-2 immunity by innate lymphoid cells. Clinical and Experimental Allergy 45(1): 9-20, 2015

Anti-microbial Functions of Group 3 Innate Lymphoid Cells in Gut-Associated Lymphoid Tissues Are Regulated by G-Protein-Coupled Receptor 183. Cell Reports 23(13): 3750-3758, 2018

CD56 Expression Marks Human Group 2 Innate Lymphoid Cell Divergence from a Shared NK Cell and Group 3 Innate Lymphoid Cell Developmental Pathway. Immunity 49(3): 464-476.E4, 2018

G9a regulates group 2 innate lymphoid cell development by repressing the group 3 innate lymphoid cell program. Journal of Experimental Medicine 213(7): 1153-1162, 2017

Regulation of Eosinophil and Group 2 Innate Lymphoid Cell Trafficking in Asthma. Frontiers in Medicine 4: 136, 2017

STAT1 Represses Cytokine-Producing Group 2 and Group 3 Innate Lymphoid Cells during Viral Infection. Journal of Immunology 199(2): 510-519, 2017