+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Relationships among rat ultrasonic vocalizations, behavioral measures of striatal dopamine loss, and striatal tyrosine hydroxylase immunoreactivity at acute and chronic time points following unilateral 6-hydroxydopamine-induced dopamine depletion



Relationships among rat ultrasonic vocalizations, behavioral measures of striatal dopamine loss, and striatal tyrosine hydroxylase immunoreactivity at acute and chronic time points following unilateral 6-hydroxydopamine-induced dopamine depletion



Behavioural Brain Research 291: 361-371



Voice deficits in Parkinson disease (PD) emerge early in the disease process, but do not improve with standard treatments targeting dopamine. Experimental work in the rat shows that severe and chronic unilateral nigrostriatal dopamine depletion with 6-OHDA results in decreased intensity, bandwidth, and complexity of ultrasonic vocalizations. However, it is unclear if mild/acute dopamine depletion, paralleling earlier stages of PD, results in vocalization deficits, or to what degree vocalization parameters are correlated with other dopamine-dependent indicators of lesion severity or percent of tyrosine hydroxylase (%TH) loss. Here, we assayed ultrasonic vocalizations, forelimb asymmetry, and apomorphine rotations in rats with a range of unilateral dopamine loss resulting from 6-OHDA or vehicle control infusions to the medial forebrain bundle at acute (72 h) and chronic (4 weeks) time points post-infusion. The %TH loss was evaluated at 4 weeks. At 72 h, forelimb asymmetry and %TH loss were significantly correlated, while at 4 weeks, all measures of lesion severity were significantly correlated with each other. Call complexity was significantly correlated with all measures of lesion severity at 72 h but only with %TH loss at 4 weeks. Bandwidth was correlated with forelimb asymmetry at both time points. Duration was significantly correlated with all dopamine depletion measures at 4 weeks. Notably, not all parameters were affected universally or equally across time. These results suggest that vocalization deficits may be a sensitive index of acute and mild catecholamine loss and further underscores the need to characterize the neural mechanisms underlying vocal deficits in PD.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 058732229

Download citation: RISBibTeXText

PMID: 26026785

DOI: 10.1016/j.bbr.2015.05.042


Related references

Cyclosporin A attenuates the decrease in tyrosine hydroxylase immunoreactivity in nigrostriatal dopaminergic neurons and in striatal dopamine content in rats with intrastriatal injection of 6-hydroxydopamine. Experimental Neurology 146(2): 526-535, 1997

Striatal dopamine synthesis after chronic administration of low doses of apo morphine or spiperone conditions of nigro striatal impulse flow may mask changes in tyrosine hydroxylase activity. Federation Proceedings 43(4): ABSTRACT 3747, 1984

Apomorphine-induced alterations in striatal and substantia nigra pars reticulata glutamate following unilateral loss of striatal dopamine. Experimental Neurology 193(1): 131-140, 2005

Behavioral motor recovery in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-lesioned squirrel monkey (Saimiri sciureus): changes in striatal dopamine and expression of tyrosine hydroxylase and dopamine transporter proteins. Journal of Neuroscience Research 83(2): 332-347, 2006

Destruction of post-synaptic dopamine receptors prevents neuroleptic-induced activation of striatal tyrosine hydroxylase but not dopamine synthesis stimulation. Life Sciences 23(7): 691-696, 1978

Differential response of striatal dopamine and muscarinic cholinergic receptor subtypes to the loss of dopamine i. effects of intranigral or intracerebroventricular 6 hydroxydopamine lesions of the mesostriatal dopamine system. Experimental Neurology 113(3): 261-276, 1991

Tyrosine hydroxylase content of residual striatal dopamine nerve terminals following 6-hydroxydopamine administration: a flow cytometric study. Journal of Neurochemistry 53(3): 879-885, 1989

Stress exacerbates behavioral deficits and striatal dopamine loss produced by 6 hydroxydopamine. Society for Neuroscience Abstract Viewer & Itinerary Planner : Abstract No 387 4, 2002

Influence of methamphetamine on nigral and striatal tyrosine hydroxylase activity and on striatal dopamine levels. European Journal of Pharmacology 36(2): 363-371, 1976

Early behavioral changes after nigro-striatal system damage can serve as predictors of striatal dopamine depletion. Progress in Neuro-Psychopharmacology and Biological Psychiatry 23(8): 1353-1368, 1999

Early behavioral changes after nigro-striatal system damage can serve as predictors of striatal dopamine depletion. Progress in Neuro-Psychopharmacology & Biological Psychiatry 23(8): 1353-1368, 1999

Behavioral asymmetries and recovery in rats with different degrees of unilateral striatal dopamine depletion. Brain Research. 664(1-2): 178-188, 1994

Behavioral asymmetries and recovery related with different degrees of unilateral striatal dopamine depletion. Society for Neuroscience Abstracts 20(1-2): 175, 1994

Effects of intranasally applied dopamine on behavioral asymmetries in rats with unilateral 6-hydroxydopamine lesions of the nigro-striatal tract. Neuroscience 162(1): 174-183, 2009

Time-dependent changes in dopamine agonist-induced striatal Fos immunoreactivity are related to sensory neglect and its recovery after unilateral prefrontal cortex injury. Synapse 20(4): 305-315, 1995