+ Site Statistics
References:
54,258,434
Abstracts:
29,560,870
PMIDs:
28,072,757
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Release of growth-differentiation factor 15 and associations with cardiac function in adult patients with congenital heart disease



Release of growth-differentiation factor 15 and associations with cardiac function in adult patients with congenital heart disease



International Journal of Cardiology 202: 246-251



Growth-differentiation factor-15 (GDF-15), a cytokine with broad cardiac and non-cardiac activity, has diagnostic and prognostic value in various diseases, including heart failure. We aimed to investigate the release of GDF-15 in adults with congenital heart disease (ConHD), and assess the association with cardiac function and functional capacity. A total of 587 consecutive adults with ConHD (median age 33 [IQR 25-41] years, 59% men, and 90% NYHA I) underwent electrocardiography, echocardiography, venepuncture and were seen by a cardiologist. A subset of 143 patients underwent bicycle ergometry on the same day. Median plasma GDF-15 was 618 [IQR 487-867] ng/L. In 87 patients (15%), GDF-15 was above the reference value of normal (1109 ng/L). GDF-15 levels were higher in older patients (r=0.367, p<0.001). GDF-15 was higher in patients with elevated pulmonary pressure (median 1114 [IQR 796-2320 ng/L) than in patients with normal pulmonary pressure (median 606 [IQR 481-826] ng/L, p<0.001). GDF-15 correlated positively with NT-proBNP (r=0.445, p<0.001). In multivariate analysis adjusting for age, sex, and NT-proBNP, hs-TnT and hs-CRP, GDF-15 above the reference value was associated with NYHA class (odds ratio for NYHA≥II: 3.5 [95% CI 1.8-6.8], p<0.001), and decreased exercise capacity (odds ratio for workload >85%:0.2 [95% CI 0.06-0.8], p=0.018), but not with systolic ventricular function or ECG rhythm. GDF-15 is elevated in a substantial number of patients and higher in those with elevated pulmonary pressures, regardless of underlying congenital diagnosis. GDF-15 is associated with NYHA class, NT-proBNP and exercise capacity, suggesting the marker has diagnostic and potential prognostic value in adults with ConHD.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 058733641

Download citation: RISBibTeXText

PMID: 26402453

DOI: 10.1016/j.ijcard.2015.09.010


Related references

Plasma concentration of growth-differentiation factor-15 in children with congenital heart disease: relation ship to heart function and diagnostic value in heart failure. Zhongguo Dang Dai Er Ke Za Zhi 15(2): 95-98, 2013

Prognostic Value of N-Terminal Pro-B-Type Natriuretic Peptide, Troponin-T, and Growth-Differentiation Factor 15 in Adult Congenital Heart Disease. Circulation 135(3): 264-279, 2016

Right ventricular function declines after cardiac surgery in adult patients with congenital heart disease. International Journal of Cardiovascular Imaging 28(4): 755-762, 2012

N-terminal proBrain Natriuretic Peptide and its Relation with Cardiac Function in Adult Patients with Congenital Heart Disease. 2013

Associations among Depression Symptoms with Alcohol and Smoking Tobacco Use in Adult Patients with Congenital Heart Disease. Congenital Heart Disease 10(5): E243-E249, 2016

Referral of young adult patients with congenital heart disease to adult centres. The Canadian Adult Congenital Heart Network. Canadian Journal of Cardiology 12(6): 600-602, 1996

Cardiac CTA for evaluation of cardiac function in patients with congenital heart disease: the good, the bad and the ugly. International Journal of Cardiovascular Imaging 32(3): 469-470, 2017

Loss-of-function mutations in growth differentiation factor-1 (GDF1) are associated with congenital heart defects in humans. American Journal of Human Genetics 81(5): 987-994, 2007

The role of cardiac surgery in adult patients with congenital heart disease. Journal of Cardiovascular Medicine 14(5): 326-333, 2014

Growth differentiation factor 15: an additional diagnostic tool for the risk stratification of developing heart failure in patients with operated congenital heart defects?. American Heart Journal 162(1): 131-135, 2011

Relative cardiac expression of growth hormone receptor and insulin-like growth factor-I mRNA in congenital heart disease. Journal of Endocrinological Investigation 31(3): 196-200, 2008

Systolic and diastolic function of heart ventricles and their remodeling in adult patients with congenital heart disease in phase of Eisenmenger's syndrome. Likars'ka Sprava 2004(5-6): 25-29, 2004

The significance of cardiac surgery scars in adult patients with congenital heart disease. Kardiologia Polska 64(1): 51-6; Discussion 57-8, 2006

Changing practice of cardiac surgery in adult patients with congenital heart disease. Heart 91(2): 207-212, 2005

Effects of ghrelin on growth and cardiac function in infants with congenital heart disease. Pediatrics International 52(3): 358-361, 2010