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Dose to Pelvic Bone Marrow Defined with FDG-PET Predicts for Hematologic Nadirs in Anal Cancer Patients Treated with Concurrent Chemo-radiation



Dose to Pelvic Bone Marrow Defined with FDG-PET Predicts for Hematologic Nadirs in Anal Cancer Patients Treated with Concurrent Chemo-radiation



Cancer Investigation 36(5): 279-288



To investigate whether irradiated volume of pelvic active bone marrow (ACTBM) may predict decreased blood cells nadirs in anal cancer patients undergoing concurrent chemo-radiation. Forty-four patients were analyzed and pelvic active bone marrow (ACTBM) was characterized employing 18FDG-PET. Dosimetric parameters on dose-volume histograms were correlated to nadirs with generalized linear modeling. ACTBM mean dose was significantly correlated to white blood cell (β = -1.338; 95%CI: -2.455/-0.221; p = 0.020), absolute neutrophil count (β = -1.651; 95%CI: -3.284/-0.183; p = 0.048), and platelets (β = -0.031; 95%CI: -0.057/-0.004; p = 0.024) nadirs. Other dosimetric parameters were found to be correlated (ACTBM-V10,-V20,-V30and-V40). 18FDG-PET is able to define active bone marrow and may predict for decreased blood cells count nadirs.

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Accession: 058758108

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PMID: 29953269

DOI: 10.1080/07357907.2018.1479413


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