+ Site Statistics
References:
54,258,434
Abstracts:
29,560,870
PMIDs:
28,072,757
+ Search Articles
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ PDF Full Text
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Translate
+ Recently Requested

Role of the Gram-Negative Envelope Stress Response in the Presence of Antimicrobial Agents



Role of the Gram-Negative Envelope Stress Response in the Presence of Antimicrobial Agents



Trends in Microbiology 24(5): 377-390



Bacterial survival necessitates endurance of many types of antimicrobial compound. Many Gram-negative envelope stress responses, which must contend with an outer membrane and a dense periplasm containing the cell wall, have been associated with the status of protein folding, membrane homeostasis, and physiological functions such as efflux and the proton motive force (PMF). In this review, we discuss evidence that indicates an emerging role for Gram-negative envelope stress responses in enduring exposure to diverse antimicrobial substances, focusing on recent studies of the γ-proteobacterial Cpx envelope stress response.

(PDF emailed within 0-6 h: $19.90)

Accession: 058791066

Download citation: RISBibTeXText

PMID: 27068053

DOI: 10.1016/j.tim.2016.03.001


Related references

Two-component signaling and gram negative envelope stress response systems. Advances in Experimental Medicine and Biology 631: 80-110, 2008

Release of outer membrane vesicles by Gram-negative bacteria is a novel envelope stress response. Molecular Microbiology 63(2): 545-558, 2006

Production of outer membrane vesicles by Gram-negative bacteria is a novel, regulated response to envelope stress. 2007

Activity of nine oral agents against gram-positive and gram-negative bacteria encountered in community-acquired infections: Use of pharmacokinetic/pharmacodynamic breakpoints in the comparative assessment of beta-lactam and macrolide antimicrobial agents. Clinical Therapeutics 25(1): 169-177, January, 2003

Using reporter genes and the Escherichia coli ASKA overexpression library in screens for regulators of the Gram negative envelope stress response. Methods in Molecular Biology 966: 337-357, 2013

Gram-negative anaerobic bacilli: their role in infection and patterns of susceptibility to antimicrobial agents. I. Little-known Bacteroides species. Reviews of Infectious Diseases 2(6): 914-951, 1980

In vitro activity of CI-934 and other antimicrobial agents against gram-positive and gram-negative bacteria. Clinical Therapeutics 9(1): 106-118, 1986

The comparative activity of norfloxacin with other antimicrobial agents against Gram-positive and Gram-negative bacteria. Journal of Antimicrobial ChemoTherapy 11(4): 369-376, 1983

Gram-negative anaerobic bacilli: Their role in infection and patterns of susceptibility to antimicrobial agents. II. Little-known Fusobacterium species and miscellaneous genera. Reviews of Infectious Diseases 3(3): 599-626, 1981

In vitro activity of clarithromycin, cefprozil, and other common oral antimicrobial agents against gram-positive and gram-negative pathogens. Clinical Therapeutics 15(1): 107-113, 1993

Inability to adequately control antimicrobial agents on AutoMicrobic System Gram-Positive and Gram-Negative Susceptibility Cards. Journal of Clinical Microbiology 21(3): 454-456, 1985

Comparison of in vitro activity of trovafloxacin against gram-positive and gram-negative organisms with quinolones and beta-lactam antimicrobial agents. Diagnostic Microbiology and Infectious Disease 31(1): 301-311, 1998

Resistance trends and in vitro activity of tigecycline and 17 other antimicrobial agents against Gram-positive and Gram-negative organisms, including multidrug-resistant pathogens, in Germany. European Journal of Clinical Microbiology and Infectious Diseases 30(9): 1095-1103, 2011

In vitro activity of gemifloxacin and contemporary oral antimicrobial agents against 27247 Gram-positive and Gram-negative aerobic isolates: a global surveillance study. International Journal of Antimicrobial Agents 23(2): 181-196, 2004