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Role of the Membrane for Mechanosensing by Tethered Channels



Role of the Membrane for Mechanosensing by Tethered Channels



Physical Review Letters 116(25): 258101



Biologically important membrane channels are gated by force at attached tethers. Here, we generically characterize the nontrivial interplay of force, membrane tension, and channel deformations that can affect gating. A central finding is that minute conical channel deformation under force leads to significant energy release during opening. We also calculate channel-channel interactions and show that they can amplify the force sensitivity of tethered channels.

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Accession: 058791117

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PMID: 27391754

DOI: 10.1103/PhysRevLett.116.258101


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