+ Site Statistics
+ Search Articles
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ PDF Full Text
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Translate
+ Recently Requested

Role of the dysfunctional ryanodine receptor - Na(+)-Ca(2+)exchanger axis in progression of cardiovascular diseases: What we can learn from pharmacological studies?

Role of the dysfunctional ryanodine receptor - Na(+)-Ca(2+)exchanger axis in progression of cardiovascular diseases: What we can learn from pharmacological studies?

European Journal of Pharmacology 779: 91-101

Abnormal Ca(2+)homeostasis is often associated with chronic cardiovascular diseases, such as hypertension, heart failure or cardiac arrhythmias, and typically contributes to the basic ethiology of the disease. Pharmacological targeting of cardiac Ca(2+)handling has great therapeutic potential offering invaluable options for the prevention, slowing down the progression or suppression of the harmful outcomes like life threatening cardiac arrhythmias. In this review we outline the existing knowledge on the involvement of malfunction of the ryanodine receptor and the Na(+)-Ca(2+)exchanger in disturbances of Ca(2+)homeostasis and discuss important proof of concept pharmacological studies targeting these mechanisms in context of hypertension, heart failure, atrial fibrillation and ventricular arrhythmias. We emphasize the promising results of preclinical studies underpinning the potential benefits of the therapeutic strategies based on ryanodine receptor or Na(+)-Ca(2+)exchanger inhibition.

(PDF emailed within 0-6 h: $19.90)

Accession: 058791302

Download citation: RISBibTeXText

PMID: 26970182

DOI: 10.1016/j.ejphar.2016.03.016

Related references

Dysfunctional ryanodine receptors in the heart: new insights into complex cardiovascular diseases. Journal of Molecular and Cellular Cardiology 58: 225-231, 2013

Dysfunctional ryanodine receptor and cardiac hypertrophy: role of signaling molecules. American Journal of Physiology. Heart and Circulatory Physiology 300(6): H2187-H2195, 2011

Association between ryanodine receptor 2 with cardiovascular diseases. Zhonghua Xin Xue Guan Bing Za Zhi 42(5): 444-446, 2015

Pharmacological clues to calmodulin-mediated activation of skeletal ryanodine receptor using [3H]-ryanodine binding. Journal of Muscle Research and Cell Motility 21(1): 1-8, 2000

Cardiovascular and autoimmune diseases in females: The role of microvasculature and dysfunctional endothelium. Atherosclerosis 241(1): 259-263, 2016

Role of the brain-gut axis in alcohol-related gastrointestinal diseases--what can we learn from new animal models?. Journal of Physiology and Pharmacology 54 Suppl 4: 191-207, 2004

Dysfunctional endothelial progenitor cells in cardiovascular diseases: role of NADPH oxidase. Journal of Cardiovascular Pharmacology 65(1): 80-87, 2015

Ryanodine binding studies of calsequestrin-depleted heavy sarcoplasmic reticulum support a regulatory role of calsequestrin on the ryanodine receptor/Ca-2+ release channel. Biophysical Journal 66(2 PART 2): A224, 1994

Role of the ryanodine receptor in ischemic brain damage-localized reduction of ryanodine receptor binding during ischemia in hippocampus CA1. Cellular & Molecular Neurobiology 19(1): 119-131, 1999

IL-6/STAT3 signaling in mice with dysfunctional type-2 ryanodine receptor. Jak-Stat 4(4): E1158379, 2015

The ACE2/Ang(1-7)/Mas receptor axis in cardiovascular and renal diseases. Nihon Rinsho. Japanese Journal of Clinical Medicine 70(9): 1487-1491, 2012

mTOR signaling in mice with dysfunctional cardiac ryanodine receptor ion channel. Journal of Receptor, Ligand and Channel Research 8: 43-51, 2015

Dysfunctional ryanodine receptor calcium release channels in Alzheimers disease. Biochemical Society Transactions 28(1): A18, 2000

Inhibition of CaMKII does not attenuate cardiac hypertrophy in mice with dysfunctional ryanodine receptor. Plos One 9(8): E104338, 2015

Targeting the Autotaxin - Lysophosphatidic Acid Receptor Axis in Cardiovascular Diseases. Biochemical Pharmacology 2019, 2019