+ Site Statistics
References:
54,258,434
Abstracts:
29,560,870
PMIDs:
28,072,757
+ Search Articles
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ PDF Full Text
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Translate
+ Recently Requested

Role played by interleukin-6 in evoking the exercise pressor reflex in decerebrate rats: effect of femoral artery ligation



Role played by interleukin-6 in evoking the exercise pressor reflex in decerebrate rats: effect of femoral artery ligation



American Journal of Physiology. Heart and Circulatory Physiology 309(1): H166-H173



IL-6 signaling via the soluble IL-6 receptor (sIL-6r) has been shown to increase primary afferent responsiveness to noxious stimuli. This finding prompted us to test the hypothesis that IL-6 and sIL-6r would increase the exercise pressor reflex in decerebrate rats with freely perfused femoral arteries. We also tested the hypothesis that soluble glycoprotein (sgp)130, an inhibitor of IL-6/sIL-6r signaling, would decrease the exaggerated exercise pressor reflex that is found in decerebrate rats with ligated femoral arteries. In rats with freely perfused femoral arteries, coinjection of 50 ng of IL-6 and sIL-6r into the arterial supply of the hindlimb significantly increased the peak pressor response to static (control: 14 ± 3 mmHg and IL-6/sIL-6r: 17 ± 2 mmHg, P = 0.03) and intermittent isometric (control: 10 ± 2 mmHg and IL-6/sIL-6r: 15 ± 4 mmHg, P = 0.03) hindlimb muscle contraction. In rats with ligated femoral arteries, injection of 50 ng of sgp130 into the arterial supply of the hindlimb reduced the peak pressor response to static (control: 24 ± 2 mmHg and sgp130: 16 ± 3 mmHg, P = 0.01) and intermittent isometric (control: 16 ± 2 mmHg and sgp130: 13 ± 2 mmHg, P = 0.04) hindlimb muscle contraction, whereas there was no effect of sgp130 on the exercise pressor reflex in rats with freely perfused femoral arteries. We conclude that coinjection of exogenous IL-6 and sIL-6r increased the exercise pressor reflex in rats with freely perfused femoral arteries. More importantly, we also conclude that IL-6 and sIL-6r play an endogenous role in evoking the exercise pressor reflex in rats with ligated femoral arteries but not in rats with freely perfused femoral arteries.

(PDF emailed within 0-6 h: $19.90)

Accession: 058791901

Download citation: RISBibTeXText

PMID: 25910806

DOI: 10.1152/ajpheart.00195.2015


Related references

The role played by oxidative stress in evoking the exercise pressor reflex in health and simulated peripheral artery disease. Journal of Physiology 595(13): 4365-4378, 2017

Role played by acid-sensitive ion channels in evoking the exercise pressor reflex. American Journal of Physiology. Heart and Circulatory Physiology 295(4): H1720-5, 2008

Role played by purinergic receptors on muscle afferents in evoking the exercise pressor reflex. Journal of Applied Physiology 94(4): 1437-1445, 2002

Purinergic 2X receptors play a role in evoking the exercise pressor reflex in rats with peripheral artery insufficiency. American Journal of Physiology. Heart and Circulatory Physiology 306(3): H396-H404, 2014

Endoperoxide 4 receptors play a role in evoking the exercise pressor reflex in rats with simulated peripheral artery disease. Journal of Physiology 591(11): 2949-2962, 2014

Role of TNF-α in Regulating the Exercise Pressor Reflex in Rats With Femoral Artery Occlusion. Frontiers in Physiology 9: 1461, 2018

Chronic femoral artery ligation exaggerates the pressor and sympathetic nerve responses during dynamic skeletal muscle stretch in decerebrate rats. American Journal of Physiology. Heart and Circulatory Physiology 314(2): H246-H254, 2017

Chronic femoral artery occlusion augments exercise pressor reflex in decerebrated rats. American Journal of Physiology. Heart and Circulatory Physiology 299(1): H106-H113, 2010

Exercise pressor reflex in decerebrate and anesthetized rats. American Journal of Physiology. Heart and Circulatory Physiology 284(6): H2026-H2033, 2003

Blockade of the TP receptor attenuates the exercise pressor reflex in decerebrated rats with chronic femoral artery occlusion. American Journal of Physiology. Heart and Circulatory Physiology 301(5): H2140-6, 2011

Local Injections of Superoxide Dismutase Attenuate the Exercise Pressor Reflex in Rats with Femoral Artery Occlusion. Frontiers in Physiology 9: 39, 2018

Peripheral mu-opioid receptors attenuate the augmented exercise pressor reflex in rats with chronic femoral artery occlusion. American Journal of Physiology. Heart and Circulatory Physiology 299(2): H557-H565, 2010

Role played by P2X receptors in the exercise pressor reflex. FASEB Journal 16(5): A1141, March 22, 2002

Tempol attenuates the exercise pressor reflex independently of neutralizing reactive oxygen species in femoral artery ligated rats. Journal of Applied Physiology 111(4): 971-979, 2012

Blockade of acid sensing ion channels attenuates the augmented exercise pressor reflex in rats with chronic femoral artery occlusion. Journal of Physiology 589(Pt 24): 6173-6189, 2012