+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Safety Profile of PrePex Male Circumcision Device and Client Satisfaction With Adolescent Males Aged 13-17 Years in Zimbabwe



Safety Profile of PrePex Male Circumcision Device and Client Satisfaction With Adolescent Males Aged 13-17 Years in Zimbabwe



Journal of Acquired Immune Deficiency Syndromes 72(Suppl. 1): S36



The safety and efficacy of the PrePex device for voluntary medical male circumcision (VMMC) has been demonstrated in studies in Rwanda, Uganda, and Zimbabwe, leading to the conditional prequalification of the device for use in adults. Because the majority of VMMC clients in the 14 priority countries are adolescents under 18 years, research to establish the safety and efficacy of the device for males <18 years is required. One-arm, prospective study included 402 adolescents, aged 13-17 years, using PrePex device between August 2013 and January 2014 at a VMMC centre in Harare. Endpoints are number and grade of adverse events associated with device circumcision, time to complete wound healing, client satisfaction with the procedure, and outcome. The rate of medical ineligibility among adolescent males was high; 237/402 (35.9%) of study participants had to be excluded based on medical reasons. The severe/moderate adverse event rate was low at 2/402 (0.5%). No device displacements/self-removals were observed. Time to complete wound healing was shorter than in adults; 367/398 (92.2%) adolescents had completed wound healing by day 35, whereas 90% of adults had completed wound healing by day 56 as demonstrated in previous studies. Overall, adolescents were highly satisfied with the results of their circumcision. The study demonstrates that the PrePex device can be safely used in adolescents aged 13-17 years. The significant proportion of males opting for surgical circumcision and the high medical ineligibility suggest that surgical circumcision needs to be provided alongside PrePex services in programs targeting young age groups.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 058801700

Download citation: RISBibTeXText

PMID: 27331588

DOI: 10.1097/qai.0000000000000799


Related references

Safety and Acceptability of the PrePex Device When Used in Routine Male Circumcision Service Delivery During Active Surveillance in Zimbabwe. Journal of Acquired Immune Deficiency Syndromes 72(Suppl. 1): S63, 2016

Is the PrePex device an alternative for surgical male circumcision in adolescents ages 13-17 years? Findings from routine service delivery during active surveillance in Zimbabwe. Plos one 14(3): E0213399, 2019

Comparative Cost Analysis of Surgical and PrePex Device Male Circumcision in Zimbabwe and Mozambique. Journal of Acquired Immune Deficiency Syndromes 72(Suppl. 1): S96, 2016

Safety and Efficacy of the PrePex Male Circumcision Device. Jaids Journal of Acquired Immune Deficiency Syndromes 72: S43-S48, 2016

Adverse event profile of a mature voluntary medical male circumcision programme performing PrePex and surgical procedures in Zimbabwe. Journal of the International Aids Society 19(1): 21394, 2017

Evaluating Opportunities for Achieving Cost Efficiencies Through the Introduction of PrePex Device Male Circumcision in Adult VMMC Programs in Zambia and Zimbabwe. Journal of Acquired Immune Deficiency Syndromes 72 Suppl 1(): S90-S95, 2016

Safety, effectiveness and acceptability of the PrePex device for adult male circumcision in Kenya. Plos one 9(5): E95357, 2014

Safety, Feasibility, and Acceptability of the PrePex Device for Adult Male Circumcision in Malawi. Journal of Acquired Immune Deficiency Syndromes 72(Suppl. 1): S49, 2016

A Phase II Randomized Controlled Trial Comparing Safety, Procedure Time, and Cost of the PrePex™ Device to Forceps Guided Surgical Circumcision in Zimbabwe. Plos one 11(5): E0156220, 2016

Cost analysis of integrating the PrePex medical device into a voluntary medical male circumcision program in Zimbabwe. Plos one 9(5): E82533, 2014

Adverse events profile of PrePex a non-surgical device for adult male circumcision in a Ugandan urban setting. Plos one 9(1): E86631, 2014

Safety and efficacy of the PrePex device for rapid scale-up of male circumcision for HIV prevention in resource-limited settings. Journal of Acquired Immune Deficiency Syndromes 58(5): E127, 2011

The safety and acceptance of the PrePex device for non-surgical adult male circumcision in Rakai, Uganda. A non-randomized observational study. Plos one 9(8): E100008, 2014

Safety and Efficacy of the PrePex Male Circumcision Device: Results From Pilot Implementation Studies in Mozambique, South Africa, and Zambia. Journal of Acquired Immune Deficiency Syndromes 72(Suppl. 1): S43, 2016

The safety profile and acceptability of a disposable male circumcision device in Kenyan men undergoing voluntary medical male circumcision. Journal of Urology 186(5): 1923-1927, 2011