Section 59
Chapter 58,811

Schwann cell differentiation inhibits interferon-gamma induction of expression of major histocompatibility complex class Ii and intercellular adhesion molecule-1

Lisak, R.P.; Bealmear, B.; Benjamins, J.A.

Journal of Neuroimmunology 295-296: 93-99


ISSN/ISBN: 1872-8421
PMID: 27235355
DOI: 10.1016/j.jneuroim.2016.03.013
Accession: 058810363

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Interferon-gamma (IFN-γ) upregulates major histocompatibility complex class II (MHC class II) antigens and intercellular adhesion molecule-1 (ICAM-1) on Schwann cells (SC) in vitro, but in nerves of animals and patients MHC class II is primarily expressed on inflammatory cells. We investigated whether SC maturation influences their expression. IFN-γ induced MHC class II and upregulated ICAM-1; the axolemma-like signal 8-bromo cyclic adenosine monophosphate (8 Br cAMP) with IFN-γ inhibited expression. Delaying addition of 8 Br cAMP to SC already exposed to IFN-γ inhibited ongoing expression; addition of IFN-γ to SC already exposed to 8 Br cAMP resulted in minimal expression. Variability of cytokine-induced MHC class II and ICAM-1 expression by SC in vivo may represent the variability of signals from axolemma.

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