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Serum IgG antibodies to GD1a and GM1 gangliosides in elderly people



Serum IgG antibodies to GD1a and GM1 gangliosides in elderly people



Biomeditsinskaia Khimiia 62(1): 93-95



Rabota posviashchena poisku markerov nachal'nykh stadiĭ neĭrodegenerativnykh zabolevaniĭ u pozhilykh liudeĭ i predvaritel'nomu issledovaniiu rasprostranennosti étikh zabolevaniĭ u patsientov dannoĭ vozrastnoĭ gruppy. Metodom immunofermentnogo analiza v syvorotke krovi pozhilykh patsientov trekh grupp (vozrast 71-76 let, 76-81 god, 81-90 let, vsego 18 patsientov) bez klinicheskikh nevrologicheskikh simptomov opredeliali IgG-antitela protiv gangliozidov GD1a i GM1. Statisticheski znachimoe povyshennoe soderzhanie antitel protiv étikh gangliozidov bylo vyiavleno tol'ko u gruppy patsientov starshe 80 let. Poluchennye dannye svidetel'stvuiut o tom, chto posle 80 let u ranee zdorovykh lits nachinaiutsia postepenno razvivaiushchiesia neĭrodegenerativnye protsessy, vnachale ne imeiushchie vyrazhennoĭ klinicheskoĭ simptomatiki. V kachestve biokhimicheskikh markerov étikh zabolevaniĭ mozhno ispol'zovat' velichiny titrov antitel protiv gangliozidov GM1 i GD1a.

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Accession: 058833885

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PMID: 26973195


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