+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Short message service (SMS) reminders and real-time adherence monitoring improve antiretroviral therapy adherence in rural Uganda



Short message service (SMS) reminders and real-time adherence monitoring improve antiretroviral therapy adherence in rural Uganda



Aids 30(8): 1295-1300



To explore the effects of four types of short message service (SMS) plus real-time adherence monitoring on antiretroviral therapy (ART) adherence: daily reminders, weekly reminders, reminders triggered after a late or missed dose (delivered to patients), and notifications triggered by sustained adherence lapses (delivered to patient-nominated social supporters). Pilot randomized controlled trial. Sixty-three individuals initiating ART received a real-time adherence monitor and were randomized (1 : 1 : 1): (1) Scheduled SMS reminders (daily for 1 month, weekly for 2 months), then SMS reminders triggered by a late or missed dose (no monitoring signal within 2 h of expected dosing); SMS notifications to social supporters for sustained adherence lapses (no monitoring signal for >48 h) added after 3 months. (2) Triggered SMS reminders starting at enrolment; SMS notifications to social supporters added after 3 months. (3) CONTROL: No SMS. HIV RNA was determined at 9 months. Percentage adherence and adherence lapses were compared by linear generalized estimating equations and Poisson regression, respectively. Median age was 31 years, 65% were women, and median enrolment CD4 cell count was 322 cells/μl 97% took once daily tenofovir/emtricitabine/efavirenz. Compared to control, adherence was 11.1% higher (P = 0.04) and more than 48-h lapses were less frequent (IRR 0.6, P = 0.02) in the scheduled SMS arm. Adherence and more than 48-h lapses were similar in the triggered SMS arm and control. No differences in HIV RNA were seen. Scheduled SMS reminders improved ART in the context of real-time monitoring. Larger studies are needed to determine the impact of triggered reminders and role of social supporters in improving adherence.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 058845625

Download citation: RISBibTeXText

PMID: 26760452

DOI: 10.1097/qad.0000000000001021


Related references

The Meanings in the messages: how SMS reminders and real-time adherence monitoring improve antiretroviral therapy adherence in rural Uganda. Aids 30(8): 1287-1294, 2016

Improving Adherence to Antiretroviral Therapy With Triggered Real-time Text Message Reminders: The China Adherence Through Technology Study. Journal of Acquired Immune Deficiency Syndromes 69(5): 551-559, 2015

Duration of Antiretroviral Therapy Adherence Interruption Is Associated With Risk of Virologic Rebound as Determined by Real-Time Adherence Monitoring in Rural Uganda. Journal of Acquired Immune Deficiency Syndromes 70(4): 386-392, 2015

A Randomized Controlled Trial of Real-Time Electronic Adherence Monitoring With Text Message Dosing Reminders in People Starting First-Line Antiretroviral Therapy. Journal of Acquired Immune Deficiency Syndromes 70(5): 495-502, 2015

Short- and long-term effects of real-time medication monitoring with short message service (SMS) reminders for missed doses on the refill adherence of people with Type 2 diabetes: evidence from a randomized controlled trial. Diabetic Medicine 31(7): 821-828, 2014

Improving medication adherence in diabetes type 2 patients through Real Time Medication Monitoring: a randomised controlled trial to evaluate the effect of monitoring patients' medication use combined with short message service (SMS) reminders. Bmc Health Services Research 11: 5, 2011

Acceptability and Feasibility of Real-Time Antiretroviral Therapy Adherence Interventions in Rural Uganda: Mixed-Method Pilot Randomized Controlled Trial. Jmir Mhealth and Uhealth 6(5): E122, 2018

Can Short-Term Use of Electronic Patient Adherence Monitoring Devices Improve Adherence in Patients Failing Second-Line Antiretroviral Therapy? Evidence from a Pilot Study in Johannesburg, South Africa. Aids and Behavior 20(11): 2717-2728, 2016

Short message service (SMS)-based intervention to improve treatment adherence among HIV-positive youth in Uganda: focus group findings. Plos one 10(4): E0125187, 2015

Realtime adherence monitoring of antiretroviral therapy among HIV-infected adults and children in rural Uganda. Aids 27(13): 2166-2168, 2013

Feasibility of interactive text message response (ITR) as a novel, real-time measure of adherence to antiretroviral therapy for HIV+ youth. Aids and Behavior 17(6): 2237-2243, 2013

Mobile phone technologies improve adherence to antiretroviral treatment in a resource-limited setting: a randomized controlled trial of text message reminders. Aids 25(8): 1137; Reply 1138-9, 2011

Real-time adherence monitoring for HIV antiretroviral therapy. Aids and Behavior 14(6): 1340-1346, 2010

Effects of and satisfaction with short message service reminders for patient medication adherence: a randomized controlled study. Bmc Medical Informatics and Decision Making 13: 127, 2013

Timed short messaging service improves adherence and virological outcomes in HIV-1-infected patients with suboptimal adherence to antiretroviral therapy. Journal of Acquired Immune Deficiency Syndromes 58(4): E113, 2011