EurekaMag
+ Translate
+ Most Popular
The pigeon tick (Argas reflexus): its biology, ecology, and epidemiological aspects
Prevalence of hemoglobin abnormalities in Kebili (Tunisian South)
Lipogranuloma: a preventable complication of dacryocystorhinostomy
Value of basal plasma cortisol assays in the assessment of pituitary-adrenal insufficiency
Bees from the Belgian Congo. The acraensis group of Anthophora
Placing gingival retraction cord
Total serum IgE, allergy skin testing, and the radioallergosorbent test for the diagnosis of allergy in asthmatic children
Acariens plumicoles Analgesoidea parasites des oiseaux du Maroc
Injuries of terminal phalanges of the fingers in children
Biology of flowering and nectar production in pear (Pyrus communis)
Das Reliktvorkommen der Aspisviper (Vipera aspis L.) im Schwarzwald
Hydrological modelling of drained blanket peatland
Pathologic morphology and clinical significance of the anomalous origin of the left circumflex coronary artery from the right coronary artery. General review and autopsy analysis of 30 cases
Cyto genetic analyses of lymphocyte cultures after exposure to calcium cyclamate
Axelrodia riesei, a new characoid fish from Upper Rio Meta in Colombia With remarks concerning the genus Axelrodia and description of a similar, sympatric, Hyphessobrycon-species
Favorable evolution of a case of tuberculosis of pancreas under antibiotic action
RIFM fragrance ingredient safety assessment, Valencene, CAS Registry Number 4630-07-3
Parenteral microemulsions: an overview
Temperate pasture: management for grazing and conservation
Evaluation of a new coprocessed compound based on lactose and maize starch for tablet formulation
Thermal expansion and cracking of three confined water-saturated igneous rocks to 800C
Revision of the genera of the tribe Stigmoderini (Coleoptera: Buprestidae) a discussion of phylogenetic relationships
Anal tuberculosis. Report of a case
Gastric tuberculosis in the past and present
Adaptive responses of the cardiovascular system to prolonged spaceflight conditions: assessment with Holter monitoring

Short-Term Effects of Overnight Orthokeratology on Corneal Sub-basal Nerve Plexus Morphology and Corneal Sensitivity


Short-Term Effects of Overnight Orthokeratology on Corneal Sub-basal Nerve Plexus Morphology and Corneal Sensitivity



Eye and Contact Lens 44(2): 77-84



ISSN/ISBN: 1542-2321

PMID: 27243354

DOI: 10.1097/icl.0000000000000282

To assess the effects of a short period of orthokeratology (OK) on corneal sub-basal nerve plexus (SBNP) morphology and corneal sensitivity. Measurements were made in 56 right eyes of 56 subjects with low-to-moderate myopia who wore 2 OK lens designs (Group CRT: HDS 100 Paragon CRT, n=35; Group SF: Seefree; n=21) for a period of 1 month and in 15 right eyes of noncontact lens wearers as controls. The variables determined in each participant were corneal sensitivity using a Cochet-Bonnet esthesiometer and 12 SBNP variables determined on laser scanning confocal microscopy images using 3 different software packages. Correlation between SBNP architecture and corneal sensitivity was also examined. Few changes were observed over the 1-month period in the variables examined in the OK treatment and control groups. However, significant reductions were detected over time in the number of nerves in the central cornea in the groups CRT (P=0.029) and SF (P=0.043) and in central corneal sensitivity in CRT (P=0.047) along with significant increases in central and midperipheral corneal Langerhans cell counts in SF (P=0.001 and 0.048, respectively). This study provides useful data to better understand the anatomical changes induced by OK in corneal SBNP. The different response observed to the 2 OK lens designs requires further investigation.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 058846420

Download citation: RISBibTeXText

Related references

Short-term effects of overnight orthokeratology on corneal cell morphology and corneal thickness. Cornea 30(6): 646-654, 2011

Long-Term Impacts of Orthokeratology Treatment on Sub-Basal Nerve Plexus and Corneal Sensitivity Responses and Their Reversibility. Eye and Contact Lens 44(2): 91-96, 2018

Short-Term Effects of Overnight Orthokeratology on Corneal Sensitivity in Chinese Children and Adolescents. Journal of Ophthalmology 2018: 6185919, 2018

Short-term effects of overnight orthokeratology on corneal epithelial permeability and biomechanical properties. Investigative Ophthalmology and Visual Science 54(6): 3902-3911, 2013

Reduced Corneal Sensitivity and Sub-Basal Nerve Density in Long-Term Orthokeratology Lens Wear. Eye and Contact Lens 43(4): 218-224, 2017

Long-term changes in corneal morphology induced by overnight orthokeratology. Current Eye Research 36(10): 895-904, 2011

Corneal sensitivity and morphology of the corneal subbasal nerve plexus in primary congenital glaucoma. Eye 28(4): 466-471, 2014

Mapping the corneal sub-basal nerve plexus in orthokeratology lens wear using in vivo laser scanning confocal microscopy. Investigative Ophthalmology and Visual Science 53(4): 1803-1809, 2012

Changes in Corneal Subbasal Nerve Morphology and Sensitivity During Orthokeratology: Onset of Change. Ocular Surface 15(2): 227-235, 2017

Changes in corneal subbasal nerve morphology and sensitivity during orthokeratology: Recovery of change. Ocular Surface 15(2): 236-241, 2017

Relationship between contrast sensitivity and corneal shape following overnight orthokeratology. International Journal of Ophthalmology 12(2): 275-279, 2019

Effect of short-term orthokeratology lens or ordinary frame glasses wear on corneal thickness, corneal endothelial cells and vision correction in adolescents with low to moderate myopia. Bmc Ophthalmology 19(1): 242, 2019

The effects of overnight orthokeratology lens wear on corneal thickness. Investigative Ophthalmology and Visual Science 44(6): 2518-2523, 2003

Recovery of corneal irregular astigmatism, ocular higher-order aberrations, and contrast sensitivity after discontinuation of overnight orthokeratology. British Journal of Ophthalmology 93(2): 203-208, 2009

Central corneal epitheliopathy in a long-term, overnight orthokeratology lens wearer: a case report. Optometry and Vision Science: Official Publication of the American Academy of Optometry 83(10): 709-714, 2006