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Single- Versus Double-Dose Rabies Vaccination In Captive African Wild Dogs (Lycaon Pictus)



Single- Versus Double-Dose Rabies Vaccination In Captive African Wild Dogs (Lycaon Pictus)



Journal of Zoo and Wildlife Medicine 46(4): 691-698



The immune responses of 35 captive African wild dogs (Lycaon pictus) to an inactivated rabies virus vaccine were evaluated. Seventeen animals received one 1-ml dose of inactivated rabies vaccine administered intramuscularly, while 18 received two 1-ml doses given simultaneously but at different injection sites. Sera were collected from all animals prior to vaccination and intermittently from a subset of animals between 3 and 49 mo postvaccination. Rabies neutralizing serum antibody titers were measured by rapid fluorescent focus inhibition testing. Within 3 mo postvaccination, all 28 animals that were tested within that time period had seroconverted. Overall, titers were significantly higher among animals given two doses of vaccine than among those given a single dose, although this difference was no longer significant by 15 mo postvaccination. Regardless of initial dose, a single administration of inactivated rabies virus vaccine resulted in long-term elevation of titers in the African wild dogs in this study. In the two individuals followed for greater than 36 mo, both (one from each group) maintained detectable titers.

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Accession: 058859714

Download citation: RISBibTeXText

PMID: 26667524

DOI: 10.1638/2014-0060.1


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