Section 59
Chapter 58,877

Solubilisation of a 2,2-diphenyl-1-picrylhydrazyl radical in water by β-cyclodextrin to evaluate the radical-scavenging activity of antioxidants in aqueous media

Nakanishi, I.; Ohkubo, K.; Imai, K.; Kamibayashi, M.; Yoshihashi, Y.; Matsumoto, K.-i.; Fukuhara, K.; Terada, K.; Itoh, S.; Ozawa, T.; Fukuzumi, S.

Chemical Communications 51(39): 8311-8314


ISSN/ISBN: 1364-548X
PMID: 25877460
DOI: 10.1039/c5cc02236c
Accession: 058876699

A 2,2-diphenyl-1-picrylhydrazyl radical (DPPH˙) was successfully solubilised in water by β-cyclodextrin (β-CD). DPPH˙/β-CD thus obtained was demonstrated to be a powerful tool to evaluate the antioxidative activity of water-soluble antioxidants, such as ascorbate and Trolox, in aqueous buffer solutions.

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