+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Spanish Broom (Spartium junceum L.) fibers impregnated with vancomycin-loaded chitosan nanoparticles as new antibacterial wound dressing: Preparation, characterization and antibacterial activity

Spanish Broom (Spartium junceum L.) fibers impregnated with vancomycin-loaded chitosan nanoparticles as new antibacterial wound dressing: Preparation, characterization and antibacterial activity

European Journal of Pharmaceutical Sciences 99: 105-112

In this work, we propose as new wound dressing, the Spanish Broom fibers impregnated with vancomycin (VM) loaded chitosan nanoparticles. Spanish Broom fibers were extracted by patented method DiCoDe and the morphological, physical and mechanical properties were investigated. Chitosan nanoparticles were prepared by ionic gelation using different weight ratios between chitosan (CH) and tripolyphosphate (TPP). Nanoparticles were characterized in terms of size, zeta potential, yield, encapsulation efficiency, stability and drug release. Finally, the antibacterial activity against Staphylococcus aureus as well as in vitro cytotoxicity on HaCaT cells were evaluated. The best formulation CH/TPP 4:1 was selected based on the encapsulation efficiency and yield. Spanish Broom fibers impregnated with loaded nanoparticles showed an increased antibacterial activity against S. aureus compared to the same fibers containing VM without nanoparticles. Moreover, these fibers were not toxic to HaCaT keratinocytes cells. In conclusion, Spanish Broom fibers impregnated with VM loaded CH/TPP nanoparticles would appear to be a promising candidate for wound dressing application.

Please choose payment method:

(PDF emailed within 0-6 h: $19.90)

Accession: 058881451

Download citation: RISBibTeXText

PMID: 27931851

DOI: 10.1016/j.ejps.2016.11.028

Related references

Preparation, characterization, and antibacterial activity of diclofenac-loaded chitosan nanoparticles. Saudi Pharmaceutical Journal 27(1): 82-87, 2019

A new physical-chemical process for the efficient production of cellulose fibers from Spanish broom (Spartium junceum L.). Bioresource Technology 101(2): 724-729, 2010

Preparation, characterization and antibacterial activities of chitosan, N-trimethyl chitosan (TMC) and N-diethylmethyl chitosan (DEMC) nanoparticles loaded with insulin using both the ionotropic gelation and polyelectrolyte complexation methods. International Journal of Pharmaceutics 355(1-2): 299-306, 2008

Callicarpa nudiflora loaded on chitosan-collagen/organomontmorillonite composite membrane for antibacterial activity of wound dressing. International Journal of Biological Macromolecules 120(Pt B): 2279-2284, 2018

Vancomycin loaded superparamagnetic MnFe2O4 nanoparticles coated with PEGylated chitosan to enhance antibacterial activity. International Journal of Pharmaceutics 501(1-2): 326-330, 2016

Preparation and Characterization of Silver Sulfadiazine-Loaded Polyvinyl Alcohol Hydrogels as an Antibacterial Wound Dressing. Journal of Pharmaceutical Sciences 107(9): 2377-2384, 2018

Novel chitin/chitosan-glucan wound dressing: Isolation, characterization, antibacterial activity and wound healing properties. International Journal of Pharmaceutics 510(1): 86-99, 2016

New broom fiber (Spartium junceum L.) derivatives: preparation and characterization. Journal of Agricultural and Food Chemistry 55(23): 9489-9495, 2007

Preparation, characterization and evaluation of antibacterial activity of catechins and catechins-Zn complex loaded β-chitosan nanoparticles of different particle sizes. Carbohydrate Polymers 137: 82-91, 2016

Witches'-broom and fasciation diseases of Spanish broom (Spartium junceum). Informatore Fitopatologico 50(4): 61-64, 2000

Montpellier broom Genista monspessulana and Spanish broom Spartium junceum in South Africa An assessment of invasiveness and options for management. South African Journal of Botany 87: 134-145, 2013

Spartium junceum (Spanish broom) poisoning. Anales de Pediatria 81(6): E32-E33, 2014

Synthesis, Characterization of Copper-Loaded Carboxymethyl-Chitosan Nanoparticles with Effective Antibacterial Activity. Macromolecular symposia 254(1): 160-166, 2007

Chitosan finishing nonwoven textiles loaded with silver and iodide for antibacterial wound dressing applications. Biomedical Materials 10(1): 015023, 2015

The Spanish broom (Spartium junceum L.) in the Palatinate near St. Martin. Floristische Rundbriefe 29(2): 157-159, 1995