+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Spontaneous neural activity in the right superior temporal gyrus and left middle temporal gyrus is associated with insight level in obsessive-compulsive disorder



Spontaneous neural activity in the right superior temporal gyrus and left middle temporal gyrus is associated with insight level in obsessive-compulsive disorder



Journal of Affective Disorders 207: 203-211



Insight into illness is an important issue for psychiatry disorder. Although the existence of a poor insight subtype of obsessive-compulsive disorder (OCD) was recognized in the DSM-IV, and the insight level in OCD was specified further in DSM-V, the neural underpinnings of insight in OCD have been rarely explored. The present study was designed to bridge this research gap by using resting-state functional magnetic resonance imaging (fMRI). Spontaneous neural activity were examined in 19 OCD patients with good insight (OCD-GI), 18 OCD patients with poor insight (OCD-PI), and 25 healthy controls (HC) by analyzing the amplitude of low-frequency fluctuation (ALFF) in the resting state. Pearson correlation analysis was performed between regional ALFFs and insight levels among OCD patients. OCD-GI and OCD-PI demonstrated overlapping and distinct brain alterations. Notably, compared with OCD-GI, tOCD-PI had reduced ALFF in left middle temporal gyrus (MTG) and right superior temporal gyrus (STG), as well as increased ALFF in right middle occipital gyrus. Further analysis revealed that ALFF values for the left MTG and right STG were correlated negatively with insight level in patients with OCD. Relatively small sample size and not all patients were un-medicated are our major limitations. Spontaneous brain activity in left MTG and right STG may be neural underpinnings of insight in OCD. Our results suggest the great role of human temporal brain regions in understanding insight, and further underscore the importance of considering insight presentation in understanding the clinical heterogeneity of OCD.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 058892501

Download citation: RISBibTeXText

PMID: 27723545

DOI: 10.1016/j.jad.2016.08.027


Related references

Abnormal spontaneous neural activity in the medial prefrontal cortex and right superior temporal gyrus correlates with anhedonia severity in obsessive-compulsive disorder. Journal of Affective Disorders 259: 47-55, 2019

Human middle longitudinal fascicle: segregation and behavioral-clinical implications of two distinct fiber connections linking temporal pole and superior temporal gyrus with the angular gyrus or superior parietal lobule using multi-tensor tractography. Brain Imaging and Behavior 7(3): 335-352, 2013

A quantitative study on the left-right asymmetry in the area consisting of the posterior part of the superior temporal gyrus, the angular gyrus and the supramarginal gyrus. Kaibogaku Zasshi. Journal of Anatomy 53(2): 180-185, 1978

Spontaneous Neural Activity in the Superior Temporal Gyrus Recapitulates Tuning for Speech Features. Frontiers in Human Neuroscience 12: 360, 2018

Context-dependent lexical ambiguity resolution: MEG evidence for the time-course of activity in left inferior frontal gyrus and posterior middle temporal gyrus. Brain and Language 177-178: 23-36, 2018

Context-dependent lexical ambiguity resolution: MEG evidence for the time-course of activity in left inferior frontal gyrus and posterior middle temporal gyrus. Brain and Language 177-178: 23-36, 2018

Middle Temporal Gyrus Versus Inferior Temporal Gyrus Transcortical Approaches to High-Grade Astrocytomas in the Mediobasal Temporal Lobe: A Comparison of Outcomes, Functional Restoration, and Surgical Considerations. Acta Neurochirurgica. Supplement 124: 159-164, 2017

Differential fMRI responses in the left posterior superior temporal gyrus and left supramarginal gyrus to habituation and change detection in syllables and tones. Neuroimage 9(1): 135-144, 1999

Predicting conceptual processing capacity from spontaneous neuronal activity of the left middle temporal gyrus. Journal of Neuroscience 32(2): 481-489, 2012

Asymmetry of the cerebral hemispheres in man: a bridge binding the 1st and the 2d temporal gyri, superior face of the 2d temporal gyrus, and fusiform gyrus. Comptes Rendus des Seances de la Societe de Biologie et de Ses Filiales 170(1): 120-123, 1976

Magnetic resonance imaging volumetric measurements of the superior temporal gyrus, hippocampus, parahippocampal gyrus, frontal and temporal lobes in late paraphrenia. Psychological Medicine 25(3): 495-503, 1995

Temporal lobe gray matter in schizophrenia spectrum: a volumetric MRI study of the fusiform gyrus, parahippocampal gyrus, and middle and inferior temporal gyri. Schizophrenia Research 87(1-3): 116-126, 2006

Dissociation between the activity of the right middle frontal gyrus and the middle temporal gyrus in processing semantic priming. Plos one 6(8): E22368, 2011

TMS interferes with lexical-semantic retrieval in left inferior frontal gyrus and posterior middle temporal gyrus: Evidence from cyclical picture naming. Neuropsychologia 64: 24-32, 2014

Superior temporal gyrus volume abnormalities and thought disorder in left-handed schizophrenic men. American Journal of Psychiatry 156(11): 1730-1735, 1999