+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Sterile inflammation and pregnancy complications: a review

Sterile inflammation and pregnancy complications: a review

Reproduction 152(6): R277-R292

Inflammation is essential for successful embryo implantation, pregnancy maintenance and delivery. In the last decade, important advances have been made in regard to endogenous, and therefore non-infectious, initiators of inflammation, which can act through the same receptors as pathogens. These molecules are referred to as damage-associated molecular patterns (DAMPs), and their involvement in reproduction has only recently been unraveled. Even though inflammation is necessary for successful reproduction, untimely activation of inflammatory processes can have devastating effect on pregnancy outcomes. Many DAMPs, such as uric acid, high-mobility group box 1 (HMGB1), interleukin (IL)-1 and cell-free fetal DNA, have been associated with pregnancy complications, such as miscarriages, preeclampsia and preterm birth in preclinical models and in humans. However, the specific contribution of alarmins to these conditions is still under debate, as currently there is lack of information on their mechanism of action. In this review, we discuss the role of sterile inflammation in reproduction, including early implantation and pregnancy complications. Particularly, we focus on major alarmins vastly implicated in numerous sterile inflammatory processes, such as uric acid, HMGB1, IL-1α and cell-free DNA (especially that of fetal origin) while giving an overview of the potential role of other candidate alarmins.

Please choose payment method:

(PDF emailed within 0-6 h: $19.90)

Accession: 058904651

Download citation: RISBibTeXText

PMID: 27679863

DOI: 10.1530/REP-16-0453

Related references

Coagulation, inflammation, and pregnancy complications. Lancet 363(9403): 96-97, 2004

Are patients with a negative sterile speculum exam for premature rupture of membranes still at increased risk for pregnancy complications?. American Journal of Obstetrics & Gynecology 180(1 PART 2): S95, 1999

Pathogenesis of endometriosis: the role of initial infection and subsequent sterile inflammation (Review). Molecular Medicine Reports 9(1): 9-15, 2014

Review of sterile, postoperative, anterior segment inflammation following cataract extraction and intraocular lens implantation. European Journal of Ophthalmology 15(2): 224-227, 2005

Aberrant maternal inflammation as a cause of pregnancy complications: A potential therapeutic target?. Placenta 36(8): 960-966, 2016

Role of tissue factor in pregnancy complications: crosstalk between coagulation and inflammation. Thrombosis Research 127 Suppl 3: S43-S46, 2011

Radial keratotomy complicated by sterile keratitis and corneal perforation. Histopathologic case report and review of complications. Ophthalmology 92(9): 1244-1248, 1985

Inflammation in pregnancy: its roles in reproductive physiology, obstetrical complications, and fetal injury. Nutrition Reviews 65(12 Pt 2): S194-S202, 2008

Inflammation and Thrombophilia in Pregnancy Complications: Implications for Risk Assessment and Clinical Management. Cardiovascular & Hematological Disorders Drug Targets 15(3): 187-203, 2016

Inflammation in pregnancy: its roles in reproductive physiology, obstetrical complications, and fetal injury. Nutrition Reviews 65(Supplement s3): 0-0, 2007

Nanosilica-induced placental inflammation and pregnancy complications: Different roles of the inflammasome components NLRP3 and ASC. Nanotoxicology 9(5): 554-567, 2016

Identifying Key Intervention Opportunities During a Pregnancy Complicated by Diabetes: a Review of Acute Complications of Diabetes During Pregnancy. Current Diabetes Reports 16(2): 17-17, 2016

Galectins: Double-edged Swords in the Cross-roads of Pregnancy Complications and Female Reproductive Tract Inflammation and Neoplasia. Journal of Pathology and Translational Medicine 49(3): 181-208, 2015

A review of cardiovascular complications of pregnancy. Ginekologia Polska 81(4): 292-297, 2010

A review of thromboembolic complications in pregnancy. Minerva Ginecologica 62(2): 121-128, 2010